Results 41 to 50 of about 6,659,357 (265)

Effects of feeding high-moisture corn on growth performance and rumen metabolism in young Simmental bulls

Frontiers in Veterinary Science
IntroductionThis study evaluated the effects of different dietary inclusion levels of high-moisture corn (HMC) on the growth performance and rumen metabolism of young Simmental bulls.MethodsThirty-two young Simmental bulls (243.99 ± 13.52 kg) were ...
Yu Gao, Kangyu Yao, Linhai Song, Wen Jiang, Min Yang, Yuxin Zhou, Subinur Abduali, Kadriya Abdurayimu, Wei Shao, Liang Yang, Wanping Ren   +10 more
doaj   +1 more source

Review: the influence of genotypic and phenotypic factors on the comfort and welfare rates of cows during the period of global climate changes

Agraarteadus, 2021
The study of the influence of weather phenomena on behavioural and physiological processes plays an important role in the development of highly effective methods of dairy farming management. Climate and weather factors have important signification in the
Oleksandr O. Borshch, Serhii Ruban, Oleksandr V. Borshch   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effect of Soy Lecithin Supplementation in Beef Cows before Calving on Colostrum Composition and Serum Total Protein and Immunoglobulin G Concentrations in Calves

Animals, 2020
The aim of this study was to investigate the impact of soy lecithin supplementation in beef cow’s nutrition on colostrum composition and serum concentrations of immunoglobulin G (IgG) and serum total protein (STP) in calves.
Edyta Wojtas, Andrzej Zachwieja, Eliza Piksa, Anna E. Zielak-Steciwko, Antoni Szumny, Bogdan Jarosz   +5 more
doaj   +1 more source

Impact of Propylene Glycol on some Nutritional, Chemical and Technological Properties of Dairy Zaraibi Goats [PDF]

Journal of Food and Dairy Sciences, 2019
To evaluate the effects of propylene glycol (PG as powder) on some nutrition parameters (digestion coefficient and nutritive values) and some productive parameters (milk yield and composition) and its effects on the quality of milk processing forDomiatti
E. Khalifa, A. Abdel-Gawad, G. El-Emam, T. El-Sawah   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Growth performance, nutrient digestibility, fecal microbial diversity and volatile fatty acid, and blood biochemical indices of suckling donkeys fed diets supplemented with multienzymes

BMC Veterinary Research
Background As the foal grows, the amount of breast milk produced by the donkey decreases. In such cases, early supplemental feeding is particularly important to meet the growth needs of the foal.
Chao Li, Xuan Yue Li, Xiao Bin Li, Chen Ma, Hui Chen, Fan Yang   +5 more
doaj   +1 more source

Productive Performance, Hatching Egg Quality and Health Indices of Hisex Brown Laying Hens Fed Extruded Grain Amaranth

Maǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗ
The article presents results proving the feasibility of extruded amaranth grain (Amaranthus cruentus) in feeding breeding laying hens of the Hisex Brown cross (aged 25-45 weeks).
Ivan F. Gorlov, Zoya B. Komarova, Marina I. Slozhenkina, Alisa V. Rudkovskaya, Aleksandr N. Struk, Elena Y. Anisimova, Natalia V. Kalinina, Evgeniya A. Struk, Olga Y. Drobyazko   +8 more
doaj   +1 more source