Results 51 to 60 of about 6,659,357 (265)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effect of farm system and milk urea phenotype on milk yield and milk composition of dairy cows in Canterbury [PDF]

, 2021
To investigate the effect of farm system, and cow selection for milk urea nitrogen (MUN), on milk yield and milk composition, a farmlet study was carried out between October 2018 and May 2019 in Lincoln, Canterbury. A farm system with a low stocking rate
Robic, Y, Curtis, Jeff, Al-Marashdeh, Omar, Handcock, Rhiannon, Bryant, Racheal, O’Conner, P, Hague, Helen   +6 more
core  

The effects of green tea in the diet of broilers challenged with coccidiosis on their performance, carcass characteristics, intestinal mucosal morphology, blood constituents and ceca microflora

Veterinary Medicine and Science, 2022
Background Coccidiosis is an endemic protozoal disease of chickens normally controlled by ionophores. However, coccidiostats are also antibiotics, and evidence of resistance in both coccidia and bacteria may develop and reduce antibacterial activity in ...
Keyvan Jelveh, Behrouz Rasouli, Isam T. Kadim, Marina Ivanovna Slozhenkina, Ivan Fedorovich Gorlov, Alireza Seidavi, Clive J. C. Phillips   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The effects of valine, lysine and threonine and their optimal combinations on the synthesis of α-casein by MAC-T cells

Frontiers in Veterinary Science
This study aims to enhance milk production and quality in dairy cows. Using in vitro cultured MAC-T cells as a model, it seeks to investigate the effects of valine, lysine, and threonine, as well as their optimal combinations, on the synthesis of α ...
Min Yang, Xinyu Zhang, Yu Ding, Lewen Xie, Yu Gao, Kangyu Yao, Wanping Ren, Liang Yang, Yankun Zhao, Wei Shao   +9 more
doaj   +1 more source

Prevalence and Genetic Basis of Antimicrobial Resistance in Non-aureus Staphylococci Isolated from Canadian Dairy Herds

Frontiers in Microbiology, 2018
Emergence and spread of antimicrobial resistance is a major concern for the dairy industry worldwide. Objectives were to determine: (1) phenotypic and genotypic prevalence of drug-specific resistance for 25 species of non-aureus staphylococci, and (2 ...
Diego B. Nobrega, Diego B. Nobrega, Sohail Naushad, Sohail Naushad, S. Ali Naqvi, S. Ali Naqvi, Larissa A. Z. Condas, Larissa A. Z. Condas, Vineet Saini, Vineet Saini, Vineet Saini, John P. Kastelic, Christopher Luby, Christopher Luby, Jeroen De Buck, Jeroen De Buck, Herman W. Barkema, Herman W. Barkema, Herman W. Barkema   +18 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The Effects of L-citrulline Supplementation on the Athletic Performance, Physiological and Biochemical Parameters, Antioxidant Capacity, and Blood Amino Acid and Polyamine Levels in Speed-Racing Yili Horses

Animals
The objective of this study was to evaluate the effects of pre-exercise L-citrulline supplementation on the athletic performance of Yili speed-racing horses during a high-intensity exercise. On the 20th day of the experiment, blood samples were collected
Peiyao Li, Shuo Sun, Wenjie Zhang, Wen Ouyang, Xiaobin Li, Kailun Yang   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source