Results 61 to 70 of about 124,133 (262)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Response profiles of dairy cows to a single 24-h milking interval in relation with milk proteolysis, udder expansion and immune traits

Animal, 2019
An extended milking interval of 24 h (24-h milking interval (24h-MI)) constitutes the acute phase of cow adaptation to once-daily milking (ODM). A recent trial including 724 24h-MI challenges demonstrated that milk yield responses to this acute phase of ...
C. Charton, H. Larroque, S. Pochet, P. Germon, G. Lequeux, J. Guinard-Flament   +5 more
doaj   +1 more source

ESTIMATED OF GENETIC AND NON GENETIC PARAMETERS FOR DAILY TEST MILK YIELD AND FAT PERCENTAGE IN HAMDANI EWES [PDF]

Mesopotamia Journal of Agriculture, 2012
This experiment was included 655 test-days for milk yield and fat percentage in Hamdani ewes obtained from 56 ewes raised at Grdarasha station- College of Agriculture, Salahaddin University during period from 2001 t0 2002.
Al-Barzinji Y. M
doaj   +1 more source

Variation in Lactation Yield of Milk Constituents

Journal of Dairy Science, 1966
Abstract The lactation production of milk, milk fat, solids-not-fat (SNF), and total solids from cows of six breeds in seven Midwest states was used to investigate gross environmental effects on these traits and to consider correlated responses due to selection for a single trait.
R P, Blanchard, A E, Freeman, P W, Spike
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Estimation of Genetic Parameters for Milk Production Rate and Its Stability in Holstein Population

Animals
Milk production rate (MPR) refers to the rate of milk secretion per hour (kg/h), calculated from the harvested milk yield and milking interval, and it is considered an appropriate measure to evaluate the production potential of cows.
Hailiang Zhang, Qing Gao, Ao Wang, Zichen Wang, Yan Liang, Mengling Guo, Yongjiang Mao, Yachun Wang   +7 more
doaj   +1 more source

Response to Selection for Milk Yield in Holsteins

Journal of Dairy Science, 1982
Data were collected for 11 yr in five institutional herds in Virginia to determine the response to selection for milk yield and to examine correlated response in other traits. A randombred control population allowed separation of genetic and environmental effects.
O M, Meland, R E, Pearson, J M, White, W E, Vinson   +3 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Hubungan Masa Kosong dengan Produktivitas pada Sapi Perah Friesian Holstein di Baturraden, Indonesia

Media Peternakan, 2011
Productivity of dairy cows not only expresed by milk yield, but also the reproductive performance. General speaking that the milk yield depends on reproductive performance and vice versa.
T. Toharmat, B. P. Purwanto, A. Atabany, A. Anggraeni   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source