Results 91 to 100 of about 1,965,698 (303)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Hubungan Masa Kosong dengan Produktivitas pada Sapi Perah Friesian Holstein di Baturraden, Indonesia

Media Peternakan, 2011
Productivity of dairy cows not only expresed by milk yield, but also the reproductive performance. General speaking that the milk yield depends on reproductive performance and vice versa.
T. Toharmat, B. P. Purwanto, A. Atabany, A. Anggraeni   +3 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Evaluation of reference lactation length in Chios dairy sheep

Animal, 2019
Definition and establishment of a fixed reference lactation length could provide useful tools for on-farm comparison of ewes and flock management as well as genetic evaluations for the breeding programme. The objectives of this study were to (i) evaluate
Z. Basdagianni, E. Sinapis, G. Banos
doaj   +1 more source

Components of Genetic Variance in Milk Yield

Journal of Dairy Science, 1969
Abstract The purpose of this research was to determine the importance of non-additive genetic effects and genetic maternal effects in the inheritance of milk production in dairy cattle. Expressing milk yield as a deviation from herdmate average eliminated most of the variation due to herds, years, seasons, and their interactions without affecting the
A J, Lee, C R, Henderson
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Response profiles of dairy cows to a single 24-h milking interval in relation with milk proteolysis, udder expansion and immune traits

Animal, 2019
An extended milking interval of 24 h (24-h milking interval (24h-MI)) constitutes the acute phase of cow adaptation to once-daily milking (ODM). A recent trial including 724 24h-MI challenges demonstrated that milk yield responses to this acute phase of ...
C. Charton, H. Larroque, S. Pochet, P. Germon, G. Lequeux, J. Guinard-Flament   +5 more
doaj   +1 more source

Milk Yield Variation Concurrent with Conception

Journal of Dairy Science, 1991
Milk yield data from herds at the University of Illinois and the University of Wisconsin-Madison were used to characterize milk yield fluctuations concurrent with conception. Analyses were performed on 118 Illinois and 244 Wisconsin cows; milk yields were recorded for 15 d preceding confirmed conception.
E D, Harwood, E L, Jensen, D A, Wieckert, M K, Clayton   +3 more
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Genetic relationship between weaning weight and milk yield in Nguni cattle

Animal, 2018
A study was conducted to estimate the genetic relationship between weaning weight and milk yield in Nguni cattle. Milk yield data (n=125) were collected from 116 Nguni cows from Mara Research Station located in Limpopo Province and Loskop South Farm ...
L.T. Nesengani, K.A. Nephawe, J. Sebei, D. Norris, A. Maiwashe   +4 more
doaj   +1 more source