Results 241 to 250 of about 128,751 (314)

Exploring the influence of endometritis diagnostic criteria on uterine involution, milk yield and fertility in dairy cows. [PDF]

BMC Vet Res
Tobolski D, Krupa M, Polak Z, Pascottini OB, Opsomer G, Barański W.   +5 more
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Health Status of Skopelos Goats and Its Impact on Milk Yield Under Intensive and Extensive Farming Systems. [PDF]

Animals (Basel)
Korelidou V, Kalogianni AI, Arsenos G, Gelasakis AI.   +3 more
europepmc   +1 more source

The effect of energy and protein levels on milk yield and butterfat content of White Fulani cattle.

, 1968
E. A. Olaloku
openalex   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Genetic Associations of <i>ACOX2</i> Gene with Milk Yield and Composition Traits in Chinese Holstein Cows. [PDF]

Animals (Basel)
Cao H, Wang Z, Xu L, Han B, Sun D.
europepmc   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Effects of concentrate intake on blood urea nitrogen, estrogen, and IGF-1 levels in relation to pregnancy status and milk yield in smallholder dairy cows. [PDF]

Open Vet J
Utama S, Aziz F, Rizal S, Mulyati S, Mustofa I, Khairullah AR, Lestari TD, Ahmad RZ, Latifah L, Akintunde AO, Anggraini L, Lisnanti EF, Nugraha CD, Ansori ANM.   +13 more
europepmc   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Genetic inbreeding load and its individual prediction for milk yield in French dairy sheep. [PDF]

Genet Sel Evol
Antonios S, Rodríguez-Ramilo ST, Legarra A, Astruc JM, Varona L, Vitezica ZG.   +5 more
europepmc   +1 more source