Results 121 to 130 of about 5,023,389 (339)

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Mapping the Chemodynamics of the Galactic Disk Using the LAMOST and APOGEE Red Clump Stars

The Astrophysical Journal Supplement Series
A detailed measurement is made of the metallicity distributions, kinematics, and dynamics of the thin and thick disks across a large disk volume (5.0 ≤ R ≤ 15.0 kpc and ∣ Z ∣ ≤ 3.0 kpc) by using the LAMOST–APOGEE red clump stars.
Weixiang Sun, Han Shen, Biwei Jiang, Xiaowei Liu   +3 more
doaj   +1 more source

Outer Regions of the Milky Way

, 2017
With the start of the Gaia era, the time has come to address the major challenge of deriving the star formation history and evolution of the disk of our MilkyWay. Here we review our present knowledge of the outer regions of the Milky Way disk population.
A. Toomre, B.F. Burke, C.C. Lin, G. Westerhout, H.C. Harris, H.J. Rocha-Pinto, I. García-Ruiz, J. Binney, J.A. Sellwood, O.J. Eggen, P.A. Patsis, P.C. Kruit van der   +11 more
core   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Dynamical heating across the Milky Way disc using APOGEE and Gaia [PDF]

Monthly notices of the Royal Astronomical Society, 2019
The kinematics of the Milky Way disc as a function of age are well measured at the solar radius, but have not been studied over a wider range of Galactocentric radii.
J. Mackereth, J. Bovy, Henry W. Leung, R. Schiavon, Wilma H. Trick, W. Chaplin, K. Cunha, D. Feuillet, S. Majewski, M. Martig, A. Miglio, D. Nidever, M. Pinsonneault, V. S. Aguirre, J. Sobeck, J. Tayar, G. Zasowski   +16 more
semanticscholar   +1 more source

On the Corotation of Milky Way Satellites: LMC-mass Satellites Induce Apparent Motions in Outer Halo Tracers

The Astrophysical Journal
Understanding the physical mechanism behind the formation of a corotating thin plane of satellite galaxies, like the one observed around the Milky Way (MW), has been challenging.
Nicolás Garavito-Camargo, Adrian M. Price-Whelan, Jenna Samuel, Emily C. Cunningham, Ekta Patel, Andrew Wetzel, Kathryn V. Johnston, Arpit Arora, Robyn E. Sanderson, Lehman Garrison, Danny Horta   +10 more
doaj   +1 more source

The ancient Egyptian personification of the Milky Way as the Sky Goddess Nut: an astronomical and cross-cultural analysis [PDF]

The Milky Way's name and role in ancient Egyptian culture remain unclear. One suggestion is that the Milky Way may have been a celestial depiction of the sky goddess Nut. In this work, I test this association using an interdisciplinary approach. In the first part of this paper, I combine astronomical simulations of the ancient Egyptian night sky with ...
arxiv   +1 more source

Constraining Milky Way mass with Hypervelocity Stars [PDF]

, 2016
Context. Although a variety of techniques have been employed for determining the Milky Way dark matter halo mass distribution, the range of allowed masses spans both light and heavy values. Knowing the precise mass of our Galaxy is important for placing the Milky Way in a cosmological $\Lambda$CDM context. Aims.
arxiv   +1 more source

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

The Circular Velocity Curve of the Milky Way from 5 to 25 kpc [PDF]

Astrophysical Journal, 2018
We measure the circular velocity curve vc(R) of the Milky Way with the highest precision to date across Galactocentric distances of 5 ≤ R ≤ 25 kpc. Our analysis draws on the six-dimensional phase-space coordinates of ≳23,000 luminous red giant stars, for
A. Eilers, D. Hogg, H. Rix, M. Ness
semanticscholar   +1 more source