Results 141 to 150 of about 5,023,389 (339)

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Icarus Revisited: An Ancient, Metal-poor Accreted Stellar Stream in the Disk of the Milky Way

The Astrophysical Journal
The search for accreted satellites in the Galactic disk is a challenging task, to which Gaia plays a crucial role in synergy with ground-based spectroscopic surveys. In 2021, P. Re Fiorentin et al.
Paola Re Fiorentin, Alessandro Spagna, Mario G. Lattanzi, Michele Cignoni, Sara Vitali   +4 more
doaj   +1 more source

A Gaia-Enceladus Analog in the EAGLE Simulation: Insights into the Early Evolution of the Milky Way [PDF]

, 2019
We identify a simulated Milky Way analog in the EAGLE suite of cosmological hydrodynamical simulations. This galaxy not only shares similar global properties as the Milky Way, but was specifically selected because its merger history resembles that currently known for the Milky Way.
arxiv   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

The Milky Way is just an average spiral [PDF]

arXiv, 1997
It has been thought for many years that the Milky Way is an overly large spiral galaxy. Using Cephied distances to 17 spiral galaxies we calculate the true linear diameters of those galaxies. These diameters are then compared to that of the Milky Way which is found to be, at most, an averagely sized spiral galaxy.
arxiv  

Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi, Hidenori Ogata, Xu Zhang, Takumi Tashiro, Ryo Yamasaki, Jun‐ichi Kira, Noriko Isobe   +6 more
wiley   +1 more source

The Rapid Formation of the Metal-poor Milky Way

The Astrophysical Journal
Our understanding of the assembly timeline of the Milky Way has been transforming along with the dramatic increase in astrometric and spectroscopic data available over the past several years.
Turner Woody, Charlie Conroy, Phillip Cargile, Ana Bonaca, Vedant Chandra, Jiwon Jesse Han, Benjamin D. Johnson, Rohan P. Naidu, Yuan-Sen Ting   +8 more
doaj   +1 more source

Locally Cold Flows from Large-Scale Structure

, 2011
We show that the "cold" Hubble flow observed for galaxies around the Milky Way does not represent a problem in cosmology but is due to the particular geometry and dynamics of our local wall.
A. S. Szalay, Aragon-Calvo, Aragón-Calvo, Aragón-Calvo, Baryshev, Cabral, Chernin, Ekholm, Governato, Hartwick, Hawkins, Hoffman, Hoyle, Icke, Icke, J. Silk, Karachentsev, Karachentsev, Karachentsev, Klypin, Landy, M. A. Aragon-Calvo, Macciò, Martinez-Vaquero, Navarro, Peebles, Peebles, Peirani, Peirani, Sandage, Sandage, Schaap, Scoccimarro, Springel, Teerikorpi, Tully, Tully, van de Weygaert, White, Zehavi, Zel’dovich   +40 more
core   +1 more source

Globular Clusters and Satellite Galaxies: Companions to the Milky Way [PDF]

arXiv, 2009
Our Milky Way galaxy is host to a number of companions. These companions are gravitationally bound to the Milky Way and are stellar systems in their own right. They include a population of some 30 dwarf satellite galaxies (DSGs) and about 150 globular clusters (GCs). Here we discuss the relationship between GCs and DSGs using an interactive 3D model of
arxiv  

Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis

Advanced Biology, EarlyView.
Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard, Kaja Borup Løvschall, Mireia Casanovas Montasell, Clara Bakkegaard Cramer, Pere Monge Marcet, Andreas Bøtker Pedersen, Josefine Hammer Jakobsen, Alexander N. Zelikin   +7 more
wiley   +1 more source