Results 161 to 170 of about 5,065,958 (389)
The Stellar Disk Structure Revealed by the Mono-age Populations of the LAMOST Red Clump Star Sample
The Astronomical JournalUnderstanding the structure of the Galactic disk is crucial for understanding the formation and evolutionary history of the Milky Way. This study examines the structure of the Galactic disk by analyzing a sample of 138,667 primary red clump (RC) stars ...
Zheng Yu +4 more
doaj +1 more source
A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). Methods Expression profiles of GBM were downloaded from the XENA database as a training dataset to construct a ...
Jun Yang +4 more
wiley +1 more source
Advanced Biology, Volume 9, Issue 3, March 2025.Yi‐Fei‐Jie‐Du‐Tang (YFJDT), a traditional Chinese medicine, has shown potential in lung cancer treatment by targeting key pathways. This study explores the mechanisms of YFJDT using bioinformatics, xenograft models, and A549 cells, demonstrating that YFJDT downregulates HIF1A, promotes ferroptosis, and inhibits epithelial‐mesenchymal transition (EMT ...
Shanshan Wang +6 more
wiley +1 more source
The Dark Disk of the Milky Way
, 2009 Massive satellite accretions onto early galactic disks can lead to the deposition of dark matter in disk-like configurations that co-rotate with the galaxy. This phenomenon has potentially dramatic consequences for dark matter detection experiments.
Bruch +15 more
core +1 more source
Observational Constraints of Radial Migration in the Galactic Disk Driven by the Slowing Bar
The Astrophysical Journal LettersRadial migration is an important dynamical effect that has reshaped the Galactic disk, but its origin has yet to be elucidated. In this work, we present evidence that resonant dragging by the corotation of a decelerating bar could be the main driver of ...
HanYuan Zhang +9 more
doaj +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
The Age-dependent Vertical Actions of Young Stars in the Galaxy
The Astrophysical JournalStars in the Galactic disk are born on cold, nearly circular orbits with small vertical excursions. After their birth, their orbits evolve, driven by small- or large-scale perturbations in the Galactic disk’s gravitational potential.
D. N. Garzon +4 more
doaj +1 more source
Advanced Biology, EarlyView.Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang +6 more
wiley +1 more source
Exploring Dark Matter with Milky Way substructure
, 2009 The unambiguous detection of Galactic dark matter annihilation would unravel one of the most outstanding puzzles in particle physics and cosmology. Recent observations have motivated models in which the annihilation rate is boosted by the Sommerfeld ...
Abdo +8 more
core +1 more source