NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
The Three-dimensional Spatial Distribution of Interstellar Gas in the Milky Way: Implications for Cosmic Rays and High-energy Gamma-ray Emissions. [PDF]
Astrophys J, 2018 Jóhannesson G +2 more
europepmc +1 more source
ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke
Advanced Science, EarlyView.Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju +11 more
wiley +1 more source
Advanced Science, EarlyView.BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan +13 more
wiley +1 more source
Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair
Advanced Science, EarlyView.A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao +7 more
wiley +1 more source
FERMI-LAT OBSERVATIONS OF HIGH- AND INTERMEDIATE-VELOCITY CLOUDS: TRACING COSMIC RAYS IN THE HALO OF THE MILKY WAY. [PDF]
Astrophys J, 2015 Tibaldo L +12 more
europepmc +1 more source
Advanced Science, EarlyView.This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie +5 more
wiley +1 more source
The XMM-Newton Line Emission Analysis Program (X-LEAP) II: The Multi-scale Temperature Structures in the Milky Way Hot Gas [PDF]
Zhijie Qu +3 more
openalex +1 more source
Advanced Science, EarlyView.This study reveals that circPVT1 promotes the renal cell carcinoma lung metastasis and tumor progression through encoding the cP104aa peptide and directly binds with EIF4A3, which jointly regulates the target gene c‐MYC. Abstract Circular RNA (circRNA) plays a pivotal role in the pathogenesis of renal cell carcinoma (RCC).
Houliang Zhang +10 more
wiley +1 more source
A Faropenem, Linezolid, and Moxifloxacin Regimen for Both Drug-Susceptible and Multidrug-Resistant Tuberculosis in Children: FLAME Path on the Milky Way. [PDF]
Clin Infect Dis, 2016 Deshpande D +5 more
europepmc +1 more source