Results 231 to 240 of about 152,178 (295)

Dark matter constraints from observations of 25 Milky Way satellite galaxies with the Fermi Large Area Telescope [PDF]

, 2014
M. Ackermann, A. Albert, B. Anderson, L. Baldini, J. Ballet, G. Barbiellini, D. Bastieri, K. Bechtol, R. Bellazzini, E. Bissaldi, E. D. Bloom, E. Bonamente, A. Bouvier, T. J. Brandt, J. Bregeon, M. Brigida, P. Bruel, R. Buehler, S. Buson, G. A. Caliandro, R. A. Cameron, M. Caragiulo, P. A. Caraveo, C. Cecchi, E. Charles, A. Chekhtman, J. Chiang, S. Ciprini, R. Claus, J. Cohen-Tanugi, J. M. Conrad, F. D’Ammando, A. De Angelis, C. D. Dermer, S. W. Digel, E. do Couto e Silva, P. S. Drell, A. Drlica-Wagner, Rouven Essig, C. Favuzzi, E. C. Ferrara, A. Franckowiak, Y. Fukazawa, S. Funk, P. Fusco, F. Gargano, D. Gasparrini, N. Giglietto, M. Giroletti, G. Godfrey, G. A. Gomez-Vargas, I. A. Grenier, S. Guiriec, M. Gustafsson, M. Hayashida, E. Hays, J. W. Hewitt, R. E. Hughes, T. Jogler, T. Kamae, J. Knödlseder, D. Kocevski, M. Kuss, S. Larsson, L. Latronico, M. Llena Garde, F. Longo, F. Loparco, M. N. Lovellette, P. Lubrano, Gregory D. Martinez, M. Mayer, M. N. Mazziotta, P. F. Michelson, W. Mitthumsiri, Tsunefumi Mizuno, A. A. Moiseev, M. E. Monzani, A. Morselli, I. V. Moskalenko, S. Murgia, Rodrigo Nemmen, E. Nuss, T. Ohsugi, E. Orlando, J. F. Ormes, J. S. Perkins, F. Piron, G. Pivato, T. A. Porter, S. Rainò, R. Rando, M. Razzano, S. Razzaque, A. Reimer, O. Reimer, S. Ritz, M. Sánchez‐Conde, Neelima Sehgal, C. Sgrò   +99 more
openalex   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source

The role of spiral arms in Milky Way star formation [PDF]

, 2018
S. E. Ragan, T. J. T. Moore, David Eden, M. G. Hoare, J. S. Urquhart, D. Elia, S. Molinari   +6 more
openalex   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Habitability in different Milky Way stellar environments: a stellar interaction dynamical approach. [PDF]

Astrobiology, 2013
Jiménez-Torres JJ, Pichardo B, Lake G, Segura A.   +3 more
europepmc   +1 more source

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

High-energy Gamma Rays from the Milky Way: Three-dimensional Spatial Models for the Cosmic-Ray and Radiation Field Densities in the Interstellar Medium. [PDF]

Astrophys J, 2017
Porter TA, Jóhannesson G, Moskalenko IV.   +2 more
europepmc   +1 more source

Dataset for paper "Decaying dark matter signal across the Milky Way?"

, 2020
Alexey Boyarsky, Dmytro Iakubovskyi, Oleg Ruchayskiy, Denys Savchenko, Kevork N. Abazajian   +4 more
openalex   +1 more source

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk

Advanced Science, EarlyView.
This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji, Peilin Li, Haoyang Wu, Linzhuo Shen, Xiaoyun Wu, Peiyun Jiang, Yating Li, Xiaozheng Zhang, Huifeng Yue   +8 more
wiley   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source