Results 241 to 250 of about 4,796,996 (337)

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

Cosmic Rays in the Milky Way and Beyond. [PDF]

Nucl Phys B Proc Suppl, 2013
Moskalenko IV.
europepmc   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

The Three-dimensional Spatial Distribution of Interstellar Gas in the Milky Way: Implications for Cosmic Rays and High-energy Gamma-ray Emissions. [PDF]

Astrophys J, 2018
Jóhannesson G, Porter TA, Moskalenko IV.   +2 more
europepmc   +1 more source

The Properties of the Galactic Bar Implied by Gas Kinematics in the Inner Milky Way [PDF]

, 1999
Benjamin J. Weiner, J. A. Sellwood
openalex   +1 more source

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

Advanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou   +15 more
wiley   +1 more source

³ He in the Milky Way Interstellar Medium: Summary of Relevant Observations [PDF]

, 1997
T. M. Bania, Dana S. Balser, Robert T. Rood, T. L. Wilson, T. Wilson   +4 more
openalex   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

FERMI-LAT OBSERVATIONS OF HIGH- AND INTERMEDIATE-VELOCITY CLOUDS: TRACING COSMIC RAYS IN THE HALO OF THE MILKY WAY. [PDF]

Astrophys J, 2015
Tibaldo L, Digel SW, Casandjian JM, Franckowiak A, Grenier IA, Jóhannesson G, Marshall DJ, Moskalenko IV, Negro M, Orlando E, Porter TA, Reimer O, Strong AW.   +12 more
europepmc   +1 more source

Deep Hα survey of the Milky Way [PDF]

, 1998
D. Russeil, Y. M. Georgelin, P. Amram, J. L. Gach, Y. P. Georgelin, M. Marcelin   +5 more
openalex   +1 more source