Results 231 to 240 of about 5,633,642 (286)

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

open access: yesAdvanced Science, Volume 13, Issue 50, 7 September 2026.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan   +13 more
wiley   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

open access: yesAdvanced Science, Volume 13, Issue 51, 14 September 2026.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu   +9 more
wiley   +1 more source

‘It Is Your Eating Disorder Talking’: A Focus Group Study of Patients' Experience of Alliance Ruptures in Psychiatric Treatment for Eating Disorders

open access: yesCounselling and Psychotherapy Research, Volume 26, Issue 3, September 2026.
ABSTRACT Background Treatments for eating disorders (EDs) are often inadequate, and dropout rates are among the highest within psychiatry. The quality of the therapeutic alliance has proven associated with treatment outcome, but forming and maintaining a strong alliance during ED treatment often presents difficulties.
Signe Degn   +3 more
wiley   +1 more source

Evidence of star cluster migration and merger in dwarf galaxies. [PDF]

open access: yesNature
Poulain M   +10 more
europepmc   +1 more source

Impact of A‐/B‐Type Starch Granule Ratios in Reconstituted Wheat Flour on Dough and Bread Properties

open access: yesCereal Chemistry, Volume 103, Issue 5, Page 830-838, September/October 2026.
ABSTRACT Background and Objectives Wheat starch comprises two granule populations, A‐ and B‐type, whose relative proportions influence the quality of wheat‐based products. In this study, 20% of wheat flour was replaced with blends of starch mixtures (A‐/B‐type ratios 100:0–0:100) and vital wheat gluten to investigate their effects on dough and bread ...
Ah Leum Kim   +6 more
wiley   +1 more source

Comprehensive Peptide Profiling Reveals the Influence of Streptococcus Thermophilus, Lactobacillus Delbrueckii Subsp. bulgaricus, and Endogenous Milk Proteases on the Hydrolysis of Milk Proteins During Early‐Stage Lactic Acid Fermentation

open access: yesChemFoodChem, Volume 2, Issue 3, September 2026.
Untargeted peptide profiling investigates how S. thermophilus, Lb. bulgaricus, and endogenous milk enzymes impact proteolysis during early‐stage milk fermentation. ≥ 3000 identified peptides show the strongest influence of LB on the peptide profile and number of bioactive peptides. Shorter peptides are mostly formed by LB and hydrolyzed by ST.
Eva Beck   +6 more
wiley   +1 more source

Shared cloud interactions unveil a candidate binary-system supernova pair with no known analogue. [PDF]

open access: yesNat Commun
Michailidis M   +5 more
europepmc   +1 more source

PPARγ‐Dependent Pioglitazone Treatment Suppresses Neuroinflammation and Improves Cognition in Sepsis‐Associated Encephalopathy in Mice

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Pioglitazone alleviated CLP‐induced sepsis‐associated encephalopathy in mice by activating PPAR‐γ, improving survival, learning, and memory, and anxiety‐like behavior. It also protected the BBB, suppressed TLR4/NF‐κB‐associated inflammation, and reduced neuronal apoptosis, effects largely reversed by GW9662.
Jing Zhang, Peng Wang, Nan Li, Yan Gao
wiley   +1 more source

Home - About - Disclaimer - Privacy