Results 261 to 270 of about 44,509 (325)

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

open access: yesAdvanced Science, Volume 13, Issue 5, 27 January 2026.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei   +8 more
wiley   +1 more source

The chemical evolution of the Milky Way thin disk using solar twins [PDF]

open access: green
Anastasiia Plotnikova   +4 more
openalex   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

open access: yesAdvanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen   +5 more
wiley   +1 more source

The mechanical strain as a cross-linking agent for skeletal muscle ECM-derived hydrogels. [PDF]

open access: yesMater Today Bio
Merotto E   +11 more
europepmc   +1 more source

NOX2‐Driven Oxidative Stress Promotes EndMT and Uncouples Angiogenesis–Osteogenesis at the Bone–Implant Interface in Diabetes

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
NOX2‐driven oxidative stress disrupts angiogenesis–osteogenesis coupling at the diabetic bone–implant interface. Pharmacologic inhibition and endothelial‐specific NOX2 knockout restore type‐H endothelium, suppress EndMT, and improve osseointegration.
Zimei Wu   +6 more
wiley   +1 more source

The chemical enrichment histories across the Milky Way disk

open access: diamond
Valéria Cerqui   +4 more
openalex   +1 more source

A mosaic of colors: The influence of biotic and abiotic factors shaping flower color diversity across a tropical mountain ecosystem

open access: yesAmerican Journal of Botany, Volume 113, Issue 1, January 2026.
Abstract Premise Flower color diversity within communities is shaped by biotic and abiotic factors. Pollinators often prefer specific colors, and floral pigments also help protect against abiotic factors such as ultraviolet (UV) radiation, precipitation, and temperature.
Maria Gabriela Gutierrez Camargo   +4 more
wiley   +1 more source

Mapping radial abundance gradients with Gaia-ESO open clusters: Evidence of recent gas accretion in the Milky Way disk

open access: green
Marco Palla   +7 more
openalex   +1 more source

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