Results 101 to 110 of about 1,984 (304)

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Decoding the Galactic Twirl: The Downfall of Milky Way–Mass Galaxy Rotation Curves in the FIRE Simulations

The Astrophysical Journal
Recent measurements of the Milky Way rotation curve found a sharp decline at around 15–20 kpc from the center of the Galaxy, suggesting that the Galactic dark matter halo is much less massive than predicted by other dynamical tracers.
Xiaowei Ou, Lina Necib, Andrew Wetzel, Anna Frebel, Jeremy Bailin, Micah Oeur   +5 more
doaj   +1 more source

How do the dynamics of the Milky Way -- Large Magellanic Cloud system affect gamma-ray constraints on particle dark matter?

, 2022
Christopher Eckner, Francesca Calore, Denis Erkal, Sophia Lilleengen, Michael Petersen   +4 more
openalex   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

First constraints on Fuzzy Dark Matter from the dynamics of stellar streams in the Milky Way [PDF]

, 2018
N. C. Amorisco, Abraham Loeb
openalex   +1 more source

Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies

Advanced Healthcare Materials, EarlyView.
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer, Dolores J. Salander, Witold Szymanski, Johannes Graumann, Yukai Wang, Kai Zhao, Jörg W. Bartsch, María Gómez‐Serrano, Daniel Bachurski, Silke Reinartz, Elke von Pogge von Strandmann   +10 more
wiley   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Early Coformation of the Milky Way’s Thin and Thick Disks at Redshift z > 2

The Astrophysical Journal
The Milky Way serves as a template for understanding the formation and evolution of late-type massive disk galaxies since we can obtain detailed chemical and kinematic information for large samples of individual stars. However, the early formation of the
Lais Borbolato, Silvia Rossi, Hélio D. Perottoni, Guilherme Limberg, João A. S. Amarante, Anna B. A. Queiroz, Cristina Chiappini, Friedrich Anders, Rafael M. Santucci, Fabrícia O. Barbosa, João V. Nogueira-Santos   +10 more
doaj   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Accurate, Precise, and Physically Self-consistent Ages and Metallicities for 400,000 Solar Neighborhood Subgiant Branch Stars

The Astrophysical Journal
Age is the most difficult fundamental stellar parameter to infer for isolated stars. While isochrone-based ages are in general imprecise for both main-sequence dwarfs and red giants, precise isochrone-based ages can be obtained for stars on the subgiant ...
David M. Nataf, Kevin C. Schlaufman, Henrique Reggiani, Isabel Hahn   +3 more
doaj   +1 more source