Results 121 to 130 of about 3,194 (299)

Measuring the Milky Way Vertical Potential with the Phase Snail in a Model-independent Way

The Astrophysical Journal
The vertical phase-space spiral (snail) is a direct sign of disequilibrium of the Milky Way’s disk. Nevertheless, the wrapping of the phase snail contains information on the vertical potential.
Rui Guo, Zhao-Yu Li, Juntai Shen, Shude Mao, Chao Liu   +4 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Exploring substructures in the Milky Way halo

Context. The identification of stellar structures in the Galactic halo, including stellar streams and merger remnants, often relies on the dynamics of their constituent stars.
J. Schiappacasse-Ulloa, R. E. Giribaldi, L. Magrini, L. Berni, L. Spina, D. Massari   +5 more
core   +1 more source

Gas flow models in the Milky Way embedded bars

, 2008
Context. The gas distribution and dynamics in the inner Galaxy present many unknowns, such as the origin of the asymmetry of the lv-diagram of the Central Molecular Zone (CMZ).
F. Combes, Rodriguez-Fernandez, N. J., N. J. Rodriguez-Fernandez, Combes, Françoise   +3 more
core   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Decoding the Galactic Twirl: The Downfall of Milky Way–Mass Galaxy Rotation Curves in the FIRE Simulations

The Astrophysical Journal
Recent measurements of the Milky Way rotation curve found a sharp decline at around 15–20 kpc from the center of the Galaxy, suggesting that the Galactic dark matter halo is much less massive than predicted by other dynamical tracers.
Xiaowei Ou, Lina Necib, Andrew Wetzel, Anna Frebel, Jeremy Bailin, Micah Oeur   +5 more
doaj   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

The Milky Way atlas for linear filaments

Context. Filamentary structure is important for the ISM and star formation. Galactic distribution of filaments may regulate the star formation rate in the Milky Way.
Yifei Ge, Ke Wang, Baug, Tapas, Wang, Ke, Tapas Baug, Ge, Yifei   +5 more
core   +2 more sources

Planetary Nebulae Beyond the Milky Way

, 2006
In the last decade extra-galactic planetary nebulae (PNe) have gained increasing importance. Improved observational capabilities have allowed fainter and fainter PNe to be studied in galaxies well beyond the Milky Way.
Walsh, J. R, Douglas, Nigel G., Walsh, Jeremy R., Stanghellini, L, Douglas, N. G, Stanghellini, Letizia   +5 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source