Results 121 to 130 of about 45,998 (281)
Advanced Science, EarlyView.Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater +13 more
wiley +1 more source
Stellar Paternity Tests: Matching High-latitude B Stars to the Open Clusters of their Birth
The Astrophysical JournalOB stars generally form in open clusters within the Milky Way’s thin disk, so when they are found at high Galactic latitudes, it is thought that they were ejected from their birth clusters during the past few tens of millions of years.
Brandon Schweers, M. Virginia McSwain
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu +10 more
wiley +1 more source
ELABELA Targets Mitochondria to Modulate Heart Development
Advanced Science, EarlyView.The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang +22 more
wiley +1 more source
The Astrophysical JournalVery metal-poor (VMP) stars record the signatures of early accreted galaxies, making them essential tools for unraveling the early stages of Galaxy formation.
Ruizhi Zhang +11 more
doaj +1 more source
The Chemo-Dynamical Evolution Of The Milky Way Disc
, 2016 The kinematic properties of the stellar subpopulations in the Milky Way disc are linked to their radial and vertical scale lengths. On the other hand, element abundances and abundance ratios are a signature of the evolution history of the stellar components.
openaire +2 more sources
QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study
Advanced Science, EarlyView.The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda +8 more
wiley +1 more source
Formation of the Two-armed Phase Spiral from Multiple External Perturbations
The Astrophysical JournalRecent studies using the Gaia DR3 data have revealed a two-armed phase spiral in the Z – V _Z phase space in the inner disk. In this study, we present new features of the two-armed phase spiral revealed by the Gaia data and a new mechanism to explain ...
Junxian Lin +5 more
doaj +1 more source
Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
The Astrophysical JournalRecent observations indicate that both the Milky Way bulge and inner halo exhibit angular momentum, although the origin and evolution of this prograde signature remain ambiguous.
Zhuohan Li +4 more
doaj +1 more source