Results 131 to 140 of about 45,998 (281)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

He Awa Whiria: The Tidal Streams of Interstellar Objects

The Astrophysical Journal
Upcoming surveys are likely to discover a new sample of interstellar objects (ISOs) within the solar system, but questions remain about the origin and distribution of this population within the Galaxy.
John C. Forbes, Michele T. Bannister, Chris Lintott, Angus Forrest, Simon Portegies Zwart, Rosemary C. Dorsey, Leah Albrow, Matthew J. Hopkins   +7 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Bar-driven Streaming Motions Mimic a Massive Bulge in the Inner Milky Way

The Astrophysical Journal
The circular speed curve of the Milky Way provides a key constraint on its mass distribution, reflecting the axisymmetric component of the gravitational potential.
Junichi Baba
doaj   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Differential Accretion of Ionized Low-velocity Gas at the Milky Way’s Disk–Halo Interface

The Astrophysical Journal
We measure line-of-sight velocities of metal absorption and H I emission along 132 QSO sight lines in order to study gas accretion and outflow at the disk–halo interface of the Milky Way.
Hannah V. Bish, Jessica K. Werk, J.E.G. Peek, Enrico Di Teodoro, Yong Zheng, Mary Putman   +5 more
doaj   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

All-sky Kinematics of the Distant Halo: The Reflex Response to the LMC

The Astrophysical Journal
The infall of the Large Magellanic Cloud (LMC) is predicted to displace the inner Milky Way (MW), imprinting an apparent “reflex motion” on the observed velocities of distant halo stars. We construct the largest all-sky spectroscopic data set of luminous
Vedant Chandra, Rohan P. Naidu, Charlie Conroy, Nicolas Garavito-Camargo, Chervin Laporte, Ana Bonaca, Phillip A. Cargile, Emily Cunningham, Jiwon Jesse Han, Benjamin D. Johnson, Hans-Walter Rix, Yuan-Sen Ting, Rebecca Woody, Dennis Zaritsky   +13 more
doaj   +1 more source

Dynamical evidence of a dark solitonic core of 109M? in the milky way

, 2020
[EN]A wavelike solution for the non-relativistic universal dark matter (wave-DM) is rapidly gaining interest, following pioneering simulations of cosmic structure as an interference pattern of coherently oscillating bosons. A prominent solitonic standing wave is predicted at the center of every galaxy, representing the ground state solution of the ...
Martino, Iván de, Broadhurst, Tom, Henry Tye, S.-H., Chiueh, Tzihong, Schive, Hsi-Yu   +4 more
openaire   +2 more sources

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source