Results 151 to 160 of about 179,998 (300)

Dynamical modelling of the Milky Way Bar/Bulge

, 2019
I review the recent progresses on the properties of the Galactic bar and bulge, and the major theoretical models and techniques to understand the Milky Way bulge. Despite these recent advances, a complete bulge formation model that explains the full kinematics and metallicity distribution is still not fully understood.
openaire   +2 more sources

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Four-hundred Very Metal-poor Stars Studied with LAMOST and Subaru. III. Dynamically Tagged Groups and Chemodynamical Properties

The Astrophysical Journal
Very metal-poor (VMP) stars record the signatures of early accreted galaxies, making them essential tools for unraveling the early stages of Galaxy formation.
Ruizhi Zhang, Tadafumi Matsuno, Haining Li, Wako Aoki, Xiang-Xiang Xue, Takuma Suda, Gang Zhao, Yuqin Chen, Miho N. Ishigaki, Jianrong Shi, Qianfan Xing, Jingkun Zhao   +11 more
doaj   +1 more source

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

The Low-α Splash Population in the Milky Way

The Astrophysical Journal Letters
The Milky Way metal-rich halo-like component, also known as the Splash, consists of old (age > 10 Gyr), metal-rich ([Fe/H] > −0.7), high- α stars, i.e., thick-disk-like chemistry, on halo-like orbits (eccentricity > 0.6).
Lais Borbolato, João A. S. Amarante, Hélio D. Perottoni, Silvia Rossi, Victor P. Debattista, Zhao-Yu Li, Nathan Deg, Tigran Khachaturyants   +7 more
doaj   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

The Rotating Bulge and Halo in the Milky Way: Evidence of Angular Momentum Transferred from the Decelerating Bar

The Astrophysical Journal
Recent observations indicate that both the Milky Way bulge and inner halo exhibit angular momentum, although the origin and evolution of this prograde signature remain ambiguous.
Zhuohan Li, Chengdong Li, Gang Zhao, Ruizhi Zhang, Xiang-Xiang Xue   +4 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

He Awa Whiria: The Tidal Streams of Interstellar Objects

The Astrophysical Journal
Upcoming surveys are likely to discover a new sample of interstellar objects (ISOs) within the solar system, but questions remain about the origin and distribution of this population within the Galaxy.
John C. Forbes, Michele T. Bannister, Chris Lintott, Angus Forrest, Simon Portegies Zwart, Rosemary C. Dorsey, Leah Albrow, Matthew J. Hopkins   +7 more
doaj   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source