Results 141 to 150 of about 179,998 (300)

Early Coformation of the Milky Way’s Thin and Thick Disks at Redshift z > 2

The Astrophysical Journal
The Milky Way serves as a template for understanding the formation and evolution of late-type massive disk galaxies since we can obtain detailed chemical and kinematic information for large samples of individual stars. However, the early formation of the
Lais Borbolato, Silvia Rossi, Hélio D. Perottoni, Guilherme Limberg, João A. S. Amarante, Anna B. A. Queiroz, Cristina Chiappini, Friedrich Anders, Rafael M. Santucci, Fabrícia O. Barbosa, João V. Nogueira-Santos   +10 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Accurate, Precise, and Physically Self-consistent Ages and Metallicities for 400,000 Solar Neighborhood Subgiant Branch Stars

The Astrophysical Journal
Age is the most difficult fundamental stellar parameter to infer for isolated stars. While isochrone-based ages are in general imprecise for both main-sequence dwarfs and red giants, precise isochrone-based ages can be obtained for stars on the subgiant ...
David M. Nataf, Kevin C. Schlaufman, Henrique Reggiani, Isabel Hahn   +3 more
doaj   +1 more source

The dynamic Milky Way in the Gaia era

The Milky Way is a relatively typical galaxy, and we are in the middle of it. That allows astronomers to observe an enormous amount of individual stars and their properties. With the success of the Gaia mission, the amount of catalogued stars is reaching into the billions.
openaire   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Formation of the Two-armed Phase Spiral from Multiple External Perturbations

The Astrophysical Journal
Recent studies using the Gaia DR3 data have revealed a two-armed phase spiral in the Z – V _Z phase space in the inner disk. In this study, we present new features of the two-armed phase spiral revealed by the Gaia data and a new mechanism to explain ...
Junxian Lin, Zhao-Yu Li, Rui Guo, Jason A. S. Hunt, T. Antoja, Chengye Cao   +5 more
doaj   +1 more source

The Chemo-Dynamical Evolution Of The Milky Way Disc

, 2016
The kinematic properties of the stellar subpopulations in the Milky Way disc are linked to their radial and vertical scale lengths. On the other hand, element abundances and abundance ratios are a signature of the evolution history of the stellar components.
openaire   +2 more sources

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Stellar Paternity Tests: Matching High-latitude B Stars to the Open Clusters of their Birth

The Astrophysical Journal
OB stars generally form in open clusters within the Milky Way’s thin disk, so when they are found at high Galactic latitudes, it is thought that they were ejected from their birth clusters during the past few tens of millions of years.
Brandon Schweers, M. Virginia McSwain
doaj   +1 more source