Results 141 to 150 of about 45,998 (281)

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Flipping of the Tidal Tails of the Ophiuchus Stream due to the Decelerating Galactic Bar

The Astrophysical Journal
The Ophiuchus stellar stream presents a puzzle due to its complicated morphology, with a substructure perpendicular to the main track (spur), a broadened tail (fanning), and a shorter than expected angular extent given its old stellar population and ...
Yong Yang, Geraint F. Lewis, Denis Erkal, Ting S. Li, Andrew P. Li, Sarah L. Martell, Lara R. Cullinane, Guilherme Limberg, Daniel B. Zucker, Joss Bland-Hawthorn, Andrew B. Pace, Gary S. Da Costa, Alexander P. Ji, Sergey E. Koposov, Kyler Kuehn, Nora Shipp, Miles Pearson, Sam A. Usman, S5 Collaboration   +18 more
doaj   +1 more source

Dynamical modelling of the Milky Way Bar/Bulge

, 2019
I review the recent progresses on the properties of the Galactic bar and bulge, and the major theoretical models and techniques to understand the Milky Way bulge. Despite these recent advances, a complete bulge formation model that explains the full kinematics and metallicity distribution is still not fully understood.
openaire   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Tracing Red Giant Members of the Globular Cluster Palomar 5 with APOGEE and Gaia

The Astrophysical Journal
The globular cluster Palomar 5 (Pal 5) is in the process of being tidally shredded as it orbits the Milky Way. Its core is currently at a heliocentric distance of ∼21 kpc, near apogalacticon (∼18 kpc), and it reaches ∼5–7 kpc at perigalacticon.
Allyson A. Sheffield, Sarah Pearson, Lenin F. Nolasco, Rachael L. Beaton, Adrian M. Price-Whelan, Rafael Guerço, Katia Cunha, Verne V. Smith   +7 more
doaj   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Dynamical Origins of Azimuthal Metallicity Variations in the Galactic Disk: Insights from Kinematic Ridges with Gaia

The Astrophysical Journal
Kinematic and spectroscopic studies in the past few years have revealed coherent azimuthal metallicity variations across the disk of the Milky Way (MW) that may be the result of dynamical process associated with nonaxisymmetric features of the Galaxy. At
Carlos Jurado, Keith Hawkins, Jason A. S. Hunt, Zoe Hackshaw, Carrie Filion, Neige Frankel, Christopher Carr   +6 more
doaj   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source