Results 171 to 180 of about 43,519 (315)

zoomies: A Tool to Infer Stellar Age from Vertical Action in Gaia Data

The Astrophysical Journal
Stellar age measurements are fundamental to understanding a wide range of astronomical processes, including Galactic dynamics, stellar evolution, and planetary system formation. However, extracting age information from main-sequence stars is complicated,
Sheila Sagear, Adrian M. Price-Whelan, Sarah Ballard, Yuxi (Lucy) Lu, Ruth Angus, David W. Hogg   +5 more
doaj   +1 more source

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

LMC Calls, Milky Way Halo Answers: Disentangling the Effects of the MW–LMC Interaction on Stellar Stream Populations

The Astrophysical Journal
The infall of the LMC into the Milky Way (MW) has dynamical implications throughout the MW’s dark matter halo. We study the impact of this merger on the statistical properties of populations of simulated stellar streams.
Richard A. N. Brooks, Nicolás Garavito-Camargo, Kathryn V. Johnston, Adrian M. Price-Whelan, Jason L. Sanders, Sophia Lilleengen   +5 more
doaj   +1 more source

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway

Advanced Science, EarlyView.
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li, Jing Zhang, Xixi Li, Xin Liu, Bo Zeng, Jiayue Luo, Huijin Wang, Hanbing Zhang, Xinya Gao   +8 more
wiley   +1 more source

A computational method to dissect colonization resistance of the gut microbiota against pathogens. [PDF]

Cell Rep Methods, 2023
Ke S, Xiao Y, Weiss ST, Chen X, Kelly CP, Liu YY.   +5 more
europepmc   +1 more source

Milky Way potentials in cold dark matter and MOdified Newtonian Dynamics. Is the Large Magellanic Cloud on a bound orbit? [PDF]

, 2008
Xufen Wu, Benoît Famaey, Gianfranco Gentile, Hagai B. Perets, Hongsheng Zhao   +4 more
openalex   +1 more source

PROS1‐MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma

Advanced Science, EarlyView.
Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang, Ye Zhang, Zhu Liu, Zhiyuan Wang, Huaqin Wang, Xiaoyu Ji, Hongyue Su, Fan Yang, Lirong Yan, Ying Xu, Hao Zhang, Wei Sun   +11 more
wiley   +1 more source

First constraints on Fuzzy Dark Matter from the dynamics of stellar streams in the Milky Way

, 2018
N. C. Amorisco, Abraham Loeb
openalex   +2 more sources

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

The history of dynamics and stellar feedback revealed by the H I filamentary structure in the disk of the Milky Way [PDF]

, 2020
J. D. Soler, H. Beuther, J. Syed, Y. Wang, L. D. Anderson, Simon C. O. Glover, P. Hennebelle, M. H. Heyer, Th. Henning, Andrés F. Izquierdo, Ralf S. Klessen, H. Linz, N. M. McClure–Griffiths, J. Ott, S. E. Ragan, M. R. Rugel, N. Schneider, Rowan J. Smith, Mattia C. Sormani, J. M. Stil, Robin G. Treß, J. S. Urquhart   +21 more
openalex   +1 more source