Results 261 to 270 of about 45,061 (325)

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

Advanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
wiley   +1 more source

Integrated In Vitro and In Silico Evaluation of the Antimicrobial and Cytotoxic Potential of <i>Calotropis procera</i> Leaf Ethanolic Extract: From GC-MS Profiling to Molecular Docking and Dynamics. [PDF]

Int J Mol Sci
Rodríguez-Macías JD, Saurith-Coronell O, Martínez Parra L, Carrascal-Hernández DC, Fuentes-Gandara F, Insuasty D, Márquez-Brazón EA.   +6 more
europepmc   +1 more source

The light and dark side of the Milky Way: from kinematics, through dynamics, to the mass of the dark matter halo

, 2013
Prajwal R. Kafle
openalex   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Effects of different cold-resistant agents and application methods on yield and cold-resistance of machine-transplanted early rice. [PDF]

Front Plant Sci
Yuan S, Qin S, Shi Q, Chen P, Tu N, Zhou W, Yi Z.   +6 more
europepmc   +1 more source

T1WI‐SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease

Advanced Science, EarlyView.
We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li, Aijun Shen, Xiaolong Gao, Chao Lin, Zongliang Huang, Qi Lv, Junjun Tang, Xiaolong Ma, Jiong Ni, Ju Tian, Jiaqi Wu, Xiaowen Xu, Wei Wang, Peijun Wang   +13 more
wiley   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Our Galaxy. [PDF]

Open Res Eur
Klaassen P, Traficante A, Beltrán M, Pattle K, Booth M, Lovell J, Marshall J, Hacar A, Gaches B, Bot C, Peretto N, Stanke T, Arzoumanian D, Duarte Cabral A, Duchêne G, Eden D, Hales A, Kauffmann J, Luppe P, Marino S, Redaelli E, Rigby A, Sánchez-Monge Á, Schisano E, Semenov D, Spezzano S, Thompson M, Wyrowski F, Cicone C, Mroczkowski T, Cordiner M, Di Mascolo L, Johnstone D, van Kampen E, Lee M, Liu D, Maccarone T, Saintonge A, Smith M, Thelen A, Wedemeyer S.   +40 more
europepmc   +1 more source

Quantification of Antibiotic Diffusion in Biofilms Using Gold Nanostar Surface‐enhanced Raman Spectroscopy

Advanced Science, EarlyView.
Gold nanostar‐enhanced Raman spectroscopy (SERS) enables real‐time, label‐free tracking of levofloxacin diffusion in intact biofilms. Nanostars embedded 16 µm below the surface detect drug arrival over time, revealing the impact of the biofilm matrix on antibiotic transport. Abstract The increased resistance to antibiotics shown by bacteria in biofilms
Wafaa Aljuhani, Yingrui Zhang, Matthew P. Wylie, Colin P. McCoy, Steven E. J. Bell   +4 more
wiley   +1 more source

Physiological Status of Rice Leaf-Roller Cnaphalocrocis medinalis (Lepidoptera: Crambidae) Adults Trapped by Sex Pheromone and Floral Odor. [PDF]

Insects
Lu J, Yao X, Shen Y, Du C, Guo Q, Du Y.
europepmc   +1 more source

Targeting the SOX9/TIMP1 Axis with iRGD‐Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer

Advanced Science, EarlyView.
This study identifies the SOX9/TIMP1 axis as a key regulator of immune evasion in gastric cancer. iRGD‐conjugated nanoparticles co‐delivering si‐SOX9, Ce6, and L‐Arg are developed to synergize with photodynamic therapy. The nanoplatform suppresses tumor growth, promotes dendritic cell maturation, and enhances CD8+ T‐cell activation, offering a ...
Banghua Zhong, Yijie Zhang, Honghu Wang, Lili Guo   +3 more
wiley   +1 more source