Results 271 to 280 of about 43,519 (315)

Proton Acceleration with Relativistic Electromagnetic Shock

Advanced Science, EarlyView.
New Ion Acceleration Mechanism! A novel cosmic‐ray proton acceleration mechanism is proposed, where relativistic electromagnetic shocks accelerate protons transversely. Hamiltonian analysis yields a scaling law linking the proton energy to the minimum longitudinal thickness of the shock.
Ting Xiao, Xiaomei Zhang, Fanqiu Kong, Xiaolong Zheng, Zheng Gong, Baifei Shen   +5 more
wiley   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: The hidden circumgalactic medium. [PDF]

Open Res Eur
Lee M, Schimek A, Cicone C, Andreani P, Popping G, Sommovigo L, Appleton PN, Bischetti M, Cantalupo S, Chen CC, Dannerbauer H, De Breuck C, Di Mascolo L, Emonts BHC, Hatziminaoglou E, Pensabene A, Rizzo F, Rybak M, Shen S, Lundgren A, Booth M, Klaassen P, Mroczkowski T, Cordiner MA, Johnstone D, van Kampen E, Liu D, Maccarone T, Saintonge A, Smith M, Thelen AE, Wedemeyer S.   +31 more
europepmc   +1 more source

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Data Requirements for Implementing the "Essential-Use" Concept in Chemical Legislation. [PDF]

Environ Sci Technol
Figuière R, Wang Z, Glüge J, Scheringer M, Siegrist A, Cousins IT.   +5 more
europepmc   +1 more source

The history of the Milky Way: The evolution of star formation, cosmic rays, metallicity, and stellar dynamics over cosmic time

Jiro Shimoda, Shu‐ichiro Inutsuka, Masahiro Nagashima   +2 more
openalex   +1 more source

DDAH1 Promotes Cisplatin Chemoresistance in Patients with Locally Advanced Nasopharyngeal Carcinoma via the EGFR‐JAK2‐STAT3 Pathway

Advanced Science, EarlyView.
This study identifies a novel mechanism of nasopharyngeal carcinoma (NPC) cisplatin chemoresistance that DDAH1 expression is associated with cisplatin resistance in NPC cells primarily through the enhancement of the phosphoinositide Janus kinase 2 (JAK2)‐signal transducer and activator of transcription 3 (STAT3) pathway.
Jin‐Hao Yang, Li Yuan, Qiu‐Yan Chen, Kai‐Qi Lan, Liang‐Ji Li, Yu‐Chen Li, Xiao‐Yun Li, Xue‐Song Sun, Lin‐Quan Tang, Sai‐Lan Liu, Hai‐Qiang Mai   +10 more
wiley   +1 more source

Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice. [PDF]

NPJ Aging
Zhu D, Wu JZ, Griffin PT, Samuelson BA, Sinclair DA, Kane AE.   +5 more
europepmc   +1 more source

STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches

Advanced Science, EarlyView.
This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan, Dongxiao Cui, Jiajian Guo, Xiaojing Ma, Jiaming Wang, Linyue Guo, Tianyu Li, Mingrui Yang, Guangrui Huang, Anlong Xu, Wenfu Ma   +10 more
wiley   +1 more source

Estimation of mass and radii for charged compact objects using a modified Chaplygin equation of state in the Buchdahl-I metric. [PDF]

PLoS One
Zahra A, Mardan SA, Saleem S, Bilal Riaz M, Kozubek T.   +4 more
europepmc   +1 more source

Unraveling Tissue‐Specific Fatty Acid Biosynthesis and Inter‐Tissue Crosstalk in Mice through Stable‐Isotope Tracing Metabolomics

Advanced Science, EarlyView.
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing, Ruohong Wang, Tianzhang Kou, Wenbin Liu, Zheng‐Jiang Zhu   +4 more
wiley   +1 more source