Results 141 to 150 of about 9,204,018 (295)

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Hydrogels Augmented With Artificial Sweeteners can Inhibit Multidrug‐Resistant Acinetobacter baumannii Growth and Biofilm Formation While Demonstrating Safety in Pre‐Clinical Pilot Human Trials

Advanced Healthcare Materials, EarlyView.
Using PVA–borax hydrogels as carriers for off‐the‐shelf artificial sweeteners to fight multidrug‐resistant A. baumannii. These soft, biocompatible hydrogels rapidly reduce bacterial viability within multidrug‐resistant A. baumannii biofilms by more than 99% within one hour and sustain antimicrobial activity over time, while demonstrating safety in both
Jie Han, Mohamed Soliman, Bin Zhang, Dominika Krawiel, Ronan R. McCarthy   +4 more
wiley   +1 more source

The APO-K2 Catalog. II. Accurate Stellar Ages for Red Giant Branch Stars across the Milky Way

The Astronomical Journal
We present stellar age determinations for 4661 red giant branch stars in the APO-K2 catalog, derived using mass estimates from K2 asteroseismology from the K2 Galactic Archaeology Program and elemental abundances from the Apache Point Galactic Evolution ...
Jack T. Warfield, Joel C. Zinn, Jessica Schonhut-Stasik, James W. Johnson, Marc H. Pinsonneault, Jennifer A. Johnson, Dennis Stello, Rachael L. Beaton, Yvonne Elsworth, Rafael A. García, Savita Mathur, Benoît Mosser, Aldo Serenelli, Jamie Tayar   +13 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Milky Way Disk

Our understanding of the Milky Way disk is rapidly improving with the recent advent of the high quality and vast amount of observational data. We summarize our current view of the structure of the Milky Way disk, such as the masses and sizes of the gas ...
Hunt, Jason A. S., Grand, Robert J. J., Ciucă, Ioana, Kawata, Daisuke   +3 more
core  

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

The accretion history of the Milky Way

Astronomy & Astrophysics
Dwarf spheroidal galaxies are known to be dominated by old stellar populations. This has led to the assumption that their gas-rich progenitors lost their gas during their infall in the Milky Way (MW) halo at distant look-back times. Here, we report a discovery of a tiny but robustly detected population of possibly young (∼1 Gyr old) and intermediate ...
Yanbin Yang, Elisabetta Caffau, Piercarlo Bonifacio, François Hammer, Jianling Wang, Gary A. Mamon   +5 more
openaire   +2 more sources

A4_16 How Long will the Milky Way Last? [PDF]

, 2011
This article investigates how long the Milky Way can sustain the current star formation rate. It is assumed in this journal that no appreciable mass is added, and neglects star death.
Edgington, Amy, Sandhu, Jasmine, Grant, Matthew, Rowe-Gurney, Naomi   +3 more
core  

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Molecular Gas Morphological Analogs for the Milky Way

The Astrophysical Journal Letters
Complete catalogs of molecular clouds in the Milky Way allow analysis of the molecular medium and the star formation properties of the Milky Way that closely follows the method used for nearby galaxies.
Neal J. Evans II, Davide Elia, Keith Hawkins, Sophia Stuber, Jiayi Sun   +4 more
doaj   +1 more source