Results 211 to 220 of about 8,242 (260)

When genes turn traitor: <i>de novo</i> transcriptomics uncovers pearl millet's rancidity machinery. [PDF]

Front Plant Sci
Kumar RR, Goswami S, Thimmegowda V, Singhal N, Mabalirajan U, Mishra GP, Jha GK, Rai GK, Praveen S, Tara Satyavathi C.   +9 more
europepmc   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Biocompatible ZnO nanoflower-infused chitosan/alginate/PVA composite for accelerated skin regeneration. [PDF]

J Mater Sci Mater Med
Reiisi S, Khalighi N, Akkoc S, Shirian S.   +3 more
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Molecular Gas, Kinematics, and OB Star Formation in the Spiral Arms of the Southern Milky Way

, 2006
A. Luna, L. Bronfman, L. Carrasco, J. May   +3 more
openalex   +2 more sources

Using spent mushroom substrate (SMS) as a casing boosted bacterial activity and enhanced the mineral profile of the Calocybe indica. [PDF]

Sci Rep
Bashir R, Mahi MH, Ferdous T, Gani MA, Elias SM, Yesmin S, Islam MS, Khandakar J.   +7 more
europepmc   +1 more source

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu, Xuefei Liu, Liwen Gu, Jingru Lian, Yuting Wang, Yixin Cheng, Lianhui Duan, Guanyin Huang, Siqi Chen, Boxi Zhao, Sailan Liu, Yufan Yang, Shuqian Zheng, Zijian Lu, Wanping Guo, Jianyang Hu, Wenjing Wang, Zhixiang Zuo, Haiqiang Mai, LinQuan Tang, Songfa Zhang, Feiqiu Wen, Xin Hong, Ling Guo   +23 more
wiley   +1 more source

Origins of the hydrothermal dolomites in Middle Permian, Sichuan Basin (SW China): Implication for the relationship with the Emeishan Large Igneous Province. [PDF]

PLoS One
Zheng H, He J, Duan X, Liu B, Herrero AT, Martín-Martín JD, Rivas EG.   +6 more
europepmc   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Modulation of nutritional composition and aroma volatiles in cultivated pork fat by culture media supplementation. [PDF]

Front Nutr
Sugama N, Lew ET, Riquelme-Guzmán C, Lee DS, Li X, Yuen JSK, Lim T, Kwan A, Liu RY, Ma YA, Frost SC, Kaplan DL.   +11 more
europepmc   +1 more source