NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex
Advanced Science, EarlyView.The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang +8 more
wiley +1 more source
A New Subclass of Carbon-enhanced Metal-poor Stars at Extremely Low Metallicity
The Astrophysical Journal LettersWe report the discovery of a new subclass of carbon-enhanced metal-poor (CEMP) stars, characterized by high absolute carbon abundances ( A (C) > 7.39) and extremely low metallicity ([Fe/H] ≤ –3.1) but notably lacking enhancements in neutron-capture ...
Young Sun Lee +6 more
doaj +1 more source
Advanced Science, EarlyView.Draper is evolutionarily conserved across most insect species. Loss of Draper inhibits autophagy activation, delaying middle silk gland degradation in the silkworm during metamorphosis. Draper interacts with autophagy ‐ related protein 3 (ATG3) to orchestrate autophagosome formation—a process essential for silk gland degradation during the larval‐pupal
Shiyu Zou +9 more
wiley +1 more source
The cosmic ray ionization and γ-ray budgets of star-forming galaxies. [PDF]
Mon Not R Astron Soc, 2023 Krumholz MR, Crocker RM, Offner SSR.
europepmc +1 more source
Milky Way-like galaxies: stellar population properties of dynamically defined discs, bulges and stellar haloes [PDF]
, 2022 Sara Ortega-Martinez +5 more
openalex +1 more source
The Gut Resistome Atlas in Preterm Infants Enables Prediction of Necrotizing Enterocolitis Onset
Advanced Science, EarlyView.The gut resistome of preterm infants and its clinical relevance remain poorly understood. This study performs in‐depth integrative analyses of 5,684 gut metagenomes from preterm infants, uncovering distinct features that diverge from term infants. Notably, the gut resistome of preterm infants converges 9 days before necrotizing enterocolitis onset ...
Shuqin Zeng +22 more
wiley +1 more source
The radial variation of the LMC-induced reflex motion of the Milky Way disc observed in the stellar halo [PDF]
Rashid Yaaqib +2 more
openalex +3 more sources
Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury
Advanced Science, EarlyView.This study demonstrates that combining Ce0.7Zr0.3O2 nanozymes with nimodipine enhances neuroprotection after traumatic brain injury. The therapy reduces oxidative stress, neuronal apoptosis, and improves blood–brain barrier integrity, with nanozymes effective at low doses.
Xinjie Hong +10 more
wiley +1 more source
The Milky Way has no in-situ halo other than the heated thick disc. Composition of the stellar halo and age-dating the last significant merger with Gaia DR2 and APOGEE [PDF]
, 2018 P. Di Matteo +7 more
openalex
Advanced Science, EarlyView.Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo +17 more
wiley +1 more source