Results 181 to 190 of about 30,715 (290)

The cosmic ray ionization and γ-ray budgets of star-forming galaxies. [PDF]

open access: yesMon Not R Astron Soc, 2023
Krumholz MR, Crocker RM, Offner SSR.
europepmc   +1 more source

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine‐Tunes Wheat Flour Gluten Properties to Improve Cookie‐Making Quality

open access: yesAdvanced Science, EarlyView.
Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu   +16 more
wiley   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

open access: yesAdvanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng   +7 more
wiley   +1 more source

Evidence of star cluster migration and merger in dwarf galaxies. [PDF]

open access: yesNature
Poulain M   +10 more
europepmc   +1 more source

Overview of the LAMOST survey in the first decade. [PDF]

open access: yesInnovation (Camb), 2022
Yan H   +26 more
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

open access: yesAdvanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian   +5 more
wiley   +1 more source

Stellar archaeology in the Milky Way halo. Variable stars and stellar populations in the new Milky Way ultra-faint dwarfs

open access: yes, 2015
We summarize results from the photometric survey of a number of ultra-faint dwarf satellites of the Milky Way. We are studying these systems in a systematic way to characterize their stellar populations and structural parameters, as well as their variable star content, with the aim of deriving hints on the formation process of the Galactic halo.
MUSELLA, ILARIA   +9 more
openaire   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

open access: yesAdvanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han   +9 more
wiley   +1 more source

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