Results 161 to 170 of about 589 (260)

The GD-1 Stellar Stream Perturber as a Core-collapsed Self-interacting Dark Matter Halo. [PDF]

Astrophys J Lett
Zhang X, Yu HB, Yang D, Nadler EO.
europepmc   +1 more source

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source

Origins and lifetimes of secular and tidal bars in simulated disc galaxies. [PDF]

Mon Not R Astron Soc
Frosst M, Obreschkow D, Ludlow A, Fraser-McKelvie A.   +3 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

A direct black-hole mass measurement in a little red dot at high redshift. [PDF]

Nature
Juodžbalis I, Marconcini C, D'Eugenio F, Maiolino R, Marconi A, Übler H, Scholtz J, Ji X, Jones GC, Perna M, Arribas S, Bennett JS, Bromm V, Bunker AJ, Carniani S, Charlot S, Cresci G, Dayal P, Egami E, Fabian A, Inayoshi K, Isobe Y, Ivey LR, Koudmani S, Laporte N, Liu B, Lyu J, Mazzolari G, Monty S, Parlanti E, Pérez-González PG, Robertson B, Schneider R, Sijacki D, Tacchella S, Trinca A, Valiante R, Volonteri M, Witstok J, Zhang S.   +39 more
europepmc   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

The photometry and kinematics studies of NGC 2509 derived from Gaia DR3. [PDF]

Sci Rep
Ahmed NM, Tadross AL.
europepmc   +1 more source

Overview of the LAMOST survey in the first decade. [PDF]

Innovation (Camb), 2022
Yan H, Li H, Wang S, Zong W, Yuan H, Xiang M, Huang Y, Xie J, Dong S, Yuan H, Bi S, Chu Y, Cui X, Deng L, Fu J, Han Z, Hou J, Li G, Liu C, Liu J, Liu X, Luo A, Shi J, Wu X, Zhang H, Zhao G, Zhao Y.   +26 more
europepmc   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Evidence of star cluster migration and merger in dwarf galaxies. [PDF]

Nature
Poulain M, Smith R, Duc PA, Marleau FR, Habas R, Durrell PR, Fensch J, Lim S, Müller O, Paudel S, Sánchez-Janssen R.   +10 more
europepmc   +1 more source