Results 151 to 160 of about 30,917 (286)
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer
Advanced Science, EarlyView.A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang +15 more
wiley +1 more source
The Milky Way's Inner Halo: Stellar Halo & Dark Matter Halo
, 2019 This presentation reviews the dynamical properties and origin of the stellar halo, and the distribution of dark matter in the inner Milky Way.
openaire +1 more source
Advanced Science, EarlyView.This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley +1 more source
Identification of Blue Horizontal-branch Stars Using Synthetic SkyMapper Colors from Gaia XP Spectra
The Astrophysical Journal Supplement SeriesBlue horizontal-branch (BHB) stars are ideal tracers for mapping the structure of the Galactic stellar halo. Traditionally, BHB sample stars are built from large-scale spectroscopic surveys utilizing their spectral features; however, the resulting sample
Guozhen Hu +11 more
doaj +1 more source
A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Advanced Science, EarlyView.This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu +16 more
wiley +1 more source
Ursa Major III/UNIONS 1: The Darkest Galaxy Ever Discovered?
The Astrophysical JournalThe recently discovered stellar system Ursa Major III/UNIONS 1 (UMa3/U1) is the faintest known Milky Way satellite to date. With a stellar mass of ${16}_{-5}^{+6}\,{M}_{\odot }$ and a half-light radius of 3 ± 1 pc, it is either the darkest galaxy ever ...
Raphaël Errani +3 more
doaj +1 more source
Advanced Science, EarlyView.THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu +10 more
wiley +1 more source
Advanced Science, EarlyView.sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang +7 more
wiley +1 more source
Phosphorus-bearing molecules PO and PN at the edge of the Galaxy. [PDF]
Nature, 2023 Koelemay LA, Gold KR, Ziurys LM.
europepmc +1 more source