Results 151 to 160 of about 13,860 (288)

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

The Orbital Anisotropy Profile of the Gaia-Sausage/Enceladus Accretion Remnant

The Astrophysical Journal
The Gaia - Sausage/Enceladus (GS/E) accretion remnant is one of the most important stellar populations in the Milky Way halo. Recent simulation-based work has suggested that the anisotropy profiles of remnants like GS/E decline towards the center and may
James M. M. Lane, Jo Bovy
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Mapping the Distant and Metal-poor Milky Way with SDSS-V

The Astrophysical Journal
The fifth-generation Sloan Digital Sky Survey (SDSS-V) is conducting the first all-sky low-resolution spectroscopic survey of the Milky Way’s (MW) stellar halo.
Vedant Chandra, Phillip A. Cargile, Alexander P. Ji, Charlie Conroy, Hans-Walter Rix, Emily Cunningham, Bruno Dias, Chervin Laporte, William Cerny, Guilherme Limberg, Avrajit Bandyopadhyay, Ana Bonaca, Andrew R. Casey, John Donor, José G. Fernández-Trincado, Peter M. Frinchaboy, Pramod Gupta, Keith Hawkins, Jennifer A. Johnson, Juna A. Kollmeier, Madeline Lucey, Ilija Medan, Szabolcs Mészáros, Sean Morrison, José Sánchez-Gallego, Andrew K. Saydjari, Conor Sayres, Kevin C. Schlaufman, Keivan G. Stassun, Jamie Tayar, Zachary Way   +30 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Characterizing the velocity anisotropy of the Milky Way's stellar halo

Modeling the Milky Way stellar halo requires well-determined density and velocity anisotropy profiles. However, it has been challenging to gather a large sample of stars with six-dimensional data that extend beyond 40 kpc to map the outer halo. Our work investigates the velocity anisotropy in the Milky Way stellar halo with more than 10,000 blue ...
Barbosa, F. O., Pérez-Villegas, A., Rossi, S., Santucci, R. M., Aguilar, L., Perottoni, H. D., Limberg, G., Borbolato, L., Nogueira-Santos, J. V.   +8 more
openaire   +2 more sources

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

The Rotating Bulge and Halo in the Milky Way: Evidence of Angular Momentum Transferred from the Decelerating Bar

The Astrophysical Journal
Recent observations indicate that both the Milky Way bulge and inner halo exhibit angular momentum, although the origin and evolution of this prograde signature remain ambiguous.
Zhuohan Li, Chengdong Li, Gang Zhao, Ruizhi Zhang, Xiang-Xiang Xue   +4 more
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Inferring Stellar Densities with Flexible Models. I. The Distribution of RR Lyrae in the Milky Way with Gaia DR3

The Astronomical Journal
Understanding the formation and evolutionary history of the Milky Way requires detailed mapping of its stellar components, which preserve fossil records of the Galaxy’s assembly through cosmic time.
Madeline Lucey, Cecilia Mateu, Adrian M. Price-Whelan, David W. Hogg, Hans-Walter Rix, Robyn E. Sanderson   +5 more
doaj   +1 more source