Results 211 to 220 of about 589 (260)

Abundant water from primordial supernovae at cosmic dawn. [PDF]

Nat Astron
Whalen DJ, Latif MA, Jessop C.
europepmc   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Efficient formation of a massive quiescent galaxy at redshift 4.9. [PDF]

Nat Astron
de Graaff A, Setton DJ, Brammer G, Cutler S, Suess KA, Labbé I, Leja J, Weibel A, Maseda MV, Whitaker KE, Bezanson R, Boogaard LA, Cleri NJ, De Lucia G, Franx M, Greene JE, Hirschmann M, Matthee J, McConachie I, Naidu RP, Oesch PA, Price SH, Rix HW, Valentino F, Wang B, Williams CC.   +25 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

A cosmic-ray loaded nascent outflow driven by a massive star cluster. [PDF]

Nat Commun
Lemoine-Goumard M, Härer L, Mohrmann L, Bernet R, Hinton J, Peron G, Reville B, Tibaldo L, Vieu T.   +8 more
europepmc   +1 more source

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

Photometric detection at 7.7 μm of a galaxy beyond redshift 14 with JWST/MIRI. [PDF]

Nat Astron
Helton JM, Rieke GH, Alberts S, Wu Z, Eisenstein DJ, Hainline KN, Carniani S, Ji Z, Baker WM, Bhatawdekar R, Bunker AJ, Cargile PA, Charlot S, Chevallard J, D'Eugenio F, Egami E, Johnson BD, Jones GC, Lyu J, Maiolino R, Pérez-González PG, Rieke MJ, Robertson B, Saxena A, Scholtz J, Shivaei I, Sun F, Tacchella S, Whitler L, Williams CC, Willmer CNA, Willott C, Witstok J, Zhu Y.   +33 more
europepmc   +1 more source

Light‐Controlled Conductive Molecular Wire in an Artificial Lipid Membrane

Advanced Science, EarlyView.
A photochromic azobenzene derivative is shown to produce a unique photoelectric response when embedded in artificial lipid membranes. In its trans state, it forms conductive “molecular wires” that enhance membrane conductivity in the dark. Light‐induced cis isomerization suppresses this effect, showing that short‐chain molecules can modulate membrane ...
Ilaria Cardace, Lorenzo Dominici, Adriano Cola, Antonio Fieramosca, Vincenzo Ardizzone, Agostina Lina Capodilupo, Bruno Rizzuti, Milena De Giorgi, Dario Ballarini, Giuseppe Gigli, Daniele Sanvitto, Luisa De Marco   +11 more
wiley   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Primordial black holes and their gravitational-wave signatures. [PDF]

Living Rev Relativ
Bagui E, Clesse S, De Luca V, Ezquiaga JM, Franciolini G, García-Bellido J, Joana C, Kumar Jain R, Kuroyanagi S, Musco I, Papanikolaou T, Raccanelli A, Renaux-Petel S, Riotto A, Ruiz Morales E, Scalisi M, Sergijenko O, Ünal C, Vennin V, Wands D, LISA Cosmology Working Group.   +20 more
europepmc   +1 more source