Results 231 to 240 of about 29,619 (304)

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

Status of Electromagnetically Accelerating Universe. [PDF]

Entropy (Basel)
Frampton PH.
europepmc   +1 more source

Strong perturbation of a super-virial Magellanic circum-galactic medium

, 2023
Locatelli N, Ponti G, Merloni A, Zheng X, Dennerl K, Haberl F, Maitra C, Sanders J, Sasaki M, Vazza F.   +9 more
europepmc   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science, EarlyView.
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
wiley   +1 more source

Strong Lensing by Galaxies. [PDF]

Space Sci Rev
Shajib AJ, Vernardos G, Collett TE, Motta V, Sluse D, Williams LLR, Saha P, Birrer S, Spiniello C, Treu T.   +9 more
europepmc   +1 more source

Uncovering a population of gravitational lens galaxies with magnified standard candle SN Zwicky. [PDF]

Nat Astron, 2023
Goobar A, Johansson J, Schulze S, Arendse N, Carracedo AS, Dhawan S, Mörtsell E, Fremling C, Yan L, Perley D, Sollerman J, Joseph R, Hinds KR, Meynardie W, Andreoni I, Bellm E, Bloom J, Collett TE, Drake A, Graham M, Kasliwal M, Kulkarni SR, Lemon C, Miller AA, Neill JD, Nordin J, Pierel J, Richard J, Riddle R, Rigault M, Rusholme B, Sharma Y, Stein R, Stewart G, Townsend A, Vinko J, Wheeler JC, Wold A.   +37 more
europepmc   +1 more source

Fn14 Controls the SIRT2‐Mediated Deacetylation of Slug to Inhibit the Metastasis of Epithelial Ovarian Cancer

Advanced Science, EarlyView.
It is reported that Fn14 inhibited EOC metastasis by regulating Slug‐mediated EMT. Furthermore, Fn14 altered the subcellular localization of SIRT2 by interacting with SIRT2, leading to reduced SIRT2 shuttling into the nucleus and subsequently promoting the acetylated degradation of Slug.
Anyue Wu, Shengze Li, Chunyang Feng, Ruiju He, Ruolan Wu, Zhijun Hu, Jinhua Huang, Wenjing Wang, Lei Huang, Lihua Qiu   +9 more
wiley   +1 more source

Abundant water from primordial supernovae at cosmic dawn. [PDF]

Nat Astron
Whalen DJ, Latif MA, Jessop C.
europepmc   +1 more source

DISCOVERY OF A NEW, POLAR-ORBITING DEBRIS STREAM IN THE MILKY WAY STELLAR HALO [PDF]

, 2009
Heidi Jo Newberg, B. Yanny, Benjamin A. Willett   +2 more
openalex   +1 more source

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source