Results 1 to 10 of about 3,621 (185)

Systemic and Brain Pharmacokinetics of Milnacipran in Mice: Comparison of Intraperitoneal and Intravenous Administration [PDF]

open access: yesPharmaceutics, 2023
Milnacipran is a dual serotonin and norepinephrine reuptake inhibitor, clinically used for the treatment of major depression or fibromyalgia. Currently, there are no studies reporting the pharmacokinetics (PK) of milnacipran after intraperitoneal (IP ...
Sounak Bagchi   +5 more
doaj   +3 more sources

Milnacipran Has an Antihyperalgesic Effect on Cisplatin-Induced Neuropathy

open access: yesPharmaceutics, 2023
(1) Background: Milnacipran is a typical serotonin–norepinephrine reuptake inhibitor and has been shown to have analgesic effects in several pain models. However, its antihyperalgesic effect in cisplatin-induced neuropathy remains unknown.
Sun Jin Cho   +6 more
doaj   +2 more sources

Disproportionality analysis of safety signals for milnacipran and levomilnacipran: a pharmacovigilance study using the FDA adverse event reporting system [PDF]

open access: yesFrontiers in Pharmacology
BackgroundMajor depressive disorder (MDD) is a global health concern, with serotonin-norepinephrine reuptake inhibitors (SNRIs) constituting a mainstay of the psychopharmacological approach to its clinical management.
Tao Huang   +6 more
doaj   +2 more sources

The Effect of Serotonin-Norepinephrine Reuptake Inhibitor Milnacipran on Anxiety-like Behaviors in Diabetic Mice

open access: yesJurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2021
Background: Diabetes mellitus is a chronic disease that causes neuronal plasticity and increased hypothalamic pituitary adrenal (HPA) axis of stress disorders.
Tuhfatul Ulya   +3 more
doaj   +2 more sources

Comparison Analysis between the Medication Efficacy of the Milnacipran and Functional Connectivity of Neural Networks in Fibromyalgia Patients

open access: yesBrain Sciences, 2020
Milnacipran is a reuptake inhibitor of both serotonin and noradrenaline, used in the treatment of fibromyalgia with severe depression. However, few studies have been conducted on the efficacies of milnacipran drug on the functional connectivity of the ...
Seong-Ho Kim   +5 more
doaj   +2 more sources

Short Term Risk of Type 2 Diabetes in Patients Using Various Antidepressants Compared with Patients Using Fluoxetine [PDF]

open access: yesPsychiatry and Clinical Psychopharmacology
Background: The objective is to compare the risk of developing type 2 diabetes (T2D) within a year in patients prescribed various antidepressants (ADs) and those prescribed fluoxetine as a control group.
Hee-Cheol Kim
doaj   +2 more sources

Antidepressants for pain management in adults with chronic pain: a network meta-analysis

open access: yesHealth Technology Assessment
Background Chronic pain is common and costly. Antidepressants are prescribed to reduce pain. However, there has not been a network meta-analysis examining all antidepressants across all chronic pain conditions, so effectiveness and safety for most ...
Hollie Birkinshaw   +9 more
doaj   +2 more sources

Milnacipran Inhibits Itch-Related Responses in Mice Through the Enhancement of Noradrenergic Transmission in the Spinal Cord

open access: yesJournal of Pharmacological Sciences, 2013
We investigated whether milnacipran, a serotonin–noradrenaline reuptake inhibitor, exhibits an antipruritic effect through the spinal action in mice.
Tsugunobu Andoh   +2 more
doaj   +1 more source

Investigation of the efficiency of various antidepressant replacement regimens in the development of SSRI-induced apathy syndrome

open access: yesНеврология, нейропсихиатрия, психосоматика, 2020
Selective serotonin reuptake inhibitors (SSRI)-induced apathy syndrome occurs in 5–20% of patients taking these drugs.Objective: to investigate the possibility and advantages of switching patients with SSRI-induced apathy to treatment with a SSRI and ...
V. E. Medvedev   +5 more
doaj   +1 more source

Depression during the COVID-19 pandemic (analysis of clinical cases)

open access: yesНеврология, нейропсихиатрия, психосоматика, 2021
Currently, in various world regions, the prevalence of depressive and anxiety disorders due to the impact of coronavirus infection is repeatedly increased compared to that in previous years.
I. Yu. Dorozhenok
doaj   +1 more source

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