Results 11 to 20 of about 3,621 (185)

Milnacipran poorly modulates pain in patients suffering from fibromyalgia: a randomized double-blind controlled study

Drug Design, Development and Therapy, 2018
Gisèle Pickering,1,2 Nicolas Macian,2 Noémie Delage,3 Pascale Picard,3 Jean-Michel Cardot,4 Sophia Sickout-Arondo,2 Fatiha Giron,2 Christian Dualé,2 Bruno Pereira,5 Fabienne Marcaillou3 1University Clermont Auvergne Neurodol ...
Pickering G, Macian N, Delage N, Picard P, Cardot JM, Sickout-Arondo S, Giron F, Dualé C, Pereira B, Marcaillou F   +9 more
doaj   +2 more sources

Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner

Journal of Pharmacological Sciences, 2017
Serotonin/noradrenaline reuptake inhibitors (SNRIs) are widely used for the treatment for major depressive disorder, but these drugs induce several side effects including increased aggression and impulsivity, which are risk factors for substance abuse ...
Iku Tsutsui-Kimura, Yu Ohmura, Takayuki Yoshida, Mitsuhiro Yoshioka   +3 more
doaj   +2 more sources

Stability-Indicating Spectrophotometric Methods for Determination of Milnacipran HCl and Duloxetine HCl in Bulk Drug and Pharmaceutical Formulations

Archives of Pharmaceutical Sciences Ain Shams University, 2019
The present study describes accurate and sensitive stability-indicating spectrophotometric methods for the determination of Milnacipran HCl in presence of its acid, base degradates, and Duloxetine HCl in presence of its base degradates; including Dual ...
Maha F. Abdel Ghany, Omar Abdel-Aziz, Nermine V. Fares, Eman Wafik Eskander   +3 more
doaj   +2 more sources

Mind and Muscle: A Retrospective Study on the Management of Psychiatric Comorbidities in Patients With Fibromyalgia Treated With Pregabalin Versus Milnacipran. [PDF]

Cureus
Background: Fibromyalgia syndrome is a debilitating chronic disease with symptoms of pain and fatigue that profoundly impact patients’ quality of life.
Arshoun A, Murdock AS, Espiridion ED.
europepmc   +2 more sources

Milnacipran and Vanillin Alleviate Fibromyalgia-Associated Depression in Reserpine-Induced Rat Model: Role of Wnt/β-Catenin Signaling. [PDF]

Mol Neurobiol
Fibromyalgia (FM) patients are highly susceptible to depression. Wnt/β-catenin signaling has shown a crucial role against depression in several studies. The FDA-approved FM drug, milnacipran (Miln), has shown antinociceptive potential against FM. Yet, no
Kamaly NA, Kamel AS, Sadik NA, Shahin NN.   +3 more
europepmc   +2 more sources

Patient Version of Guideline for Fibromyalgia (2025 Edition). [PDF]

J Evid Based Med
ABSTRACT Objective To develop an evidence‐based patient version of guideline (PVG) for fibromyalgia, aiming to improve patients’ understanding of disease symptoms and therapeutic options and to enhance their self‐management abilities. Methods Following the World Health Organization Handbook for Guideline Development (2014), a multidisciplinary working ...
Zhang Z, Zhou P, He N, Wu Z, Bo S, Chen C, Chi S, Hou N, Hu J, Jing F, Li B, Li L, Li S, Li Y, Lin Y, Luo Q, Mai J, Mu R, Ouyang R, Qin W, Shao R, Shen J, Sun X, Wang T, Wu J, Xie H, Xu X, Yan Y, Yang K, Yao Z, Ye C, Yuan Y, Zhu J, Zhao R, Zhang D, Liang D, Zeng X, Fan B, Zhai S.   +38 more
europepmc   +2 more sources

Gut microbe-derived milnacipran enhances tolerance to gut ischemia/reperfusion injury

Cell Reports Medicine, 2023
Summary There are significant differences in the susceptibility of populations to intestinal ischemia/reperfusion (I/R), but the underlying mechanisms remain elusive.
Fan Deng, Jingjuan Hu, Zebin Lin, Qishun Sun, Yue Min, Bingcheng Zhao, Zhibin Huang, Wen-juan Zhang, Wen-Kao Huang, Wei Liu, Cai Li, Ke-xuan Liu   +11 more
semanticscholar   +1 more source

Miniaturized Chip Integrated Ecological Sensor for the Quantitation of Milnacipran Hydrochloride in the Presence of Its Impurities in Dosage Form and Human Plasma

Journal of the Electrochemical Society, 2023
Modifications of sensor composition provides a way to achieve the utmost sensitivity and selectivity. Molecular imprinting, together with conducting polymers and graphite derivatives, represents a robust composite that attains better sensor performance.
Aziza E Mostafa, Ahmed Elsonbaty, Khaled Attala, Mohamed A. Abdelshakour, Randa A Abdel Salam, Ghada M. Hadad, M. Eissa   +6 more
semanticscholar   +1 more source

Pain Management in Fibromyalgia: Evaluating the Roles of Pregabalin, Duloxetine, and Milnacipran. [PDF]

Cureus
Introduction Fibromyalgia is a chronic pain disorder characterized by widespread pain, fatigue, and sleep disturbances. The purpose of this study was to compare how well duloxetine, pregabalin, and milnacipran worked for fibromyalgia patients in terms of
Faizan Ejaz K, Wani R, Akbar A, Umaira Khan Q, Ishtiaq H, Amir M, Ali AI, Khan S.   +7 more
europepmc   +2 more sources

Evaluating and Determining the Effects of Psychotropic Drugs on Motor Vehicle Driving Performance: Key Considerations of the Japanese Guideline and Criteria for Clinical Implementation of Evidence. [PDF]

Neuropsychopharmacol Rep
The Japanese guideline and criteria for evaluating and determining the effects of psychotropic drugs on motor vehicle driving performance enable the clinical implementation of evidence by assessing “persistence of clinically meaningful impairment”. ABSTRACT The cross‐national differences in automobile driving precautions stated in psychotropic drug ...
Nakabayashi T, Iwamoto K, Yamaguchi A, Konishi Y, Saji M, Yoshimura R, Kanemoto K, Aoki H, Ando M, Ozaki N.   +9 more
europepmc   +2 more sources