Results 31 to 40 of about 3,621 (185)
Based on the data available in the literature, the author has first systematized in detail the main stages of the design and clinical introduction of serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressants.
D. S. Danilov
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
A new, cost-effective and fast chromatographic method using sulfated β-cyclodextrin (SβCD) as a chiral mobile phase additive (CMPA) was developed and validated for the enantiomeric separation of milnacipran. Milnacipran is an anti-depressant drug.
P. Pathak +4 more
semanticscholar +1 more source
Milnacipran-induced premature ejaculation
Milnacipran, is noradrenalin and serotonin reuptake inhibitor, is preferred because of low side effects and well-tolerability in the treatment of depression and fibromyalgia. Yaşamın her alanında olduğu gibi, butun insanların cinsel yaşamdan zevk alması
İbrahim Gundoğmuş +2 more
doaj +1 more source
Abstract Aim Avoidance is a key maintaining factor in major depressive disorder (MDD); however, longitudinal evidence remains limited, and its association with personality traits is not fully understood. This study aimed to (1) examine the longitudinal associations among avoidance, depressive symptoms, and rumination and (2) explore the relationship ...
Ryotaro Higuchi +9 more
wiley +1 more source
Milnacipran for the management of fibromyalgia syndrome
Michelle J Ormseth, Anne E Eyler, Cara L Hammonds, Chad S BoomershineDivision of Rheumatology and Immunology, Vanderbilt University, Nashville, TN, USAAbstract: Fibromyalgia syndrome (FMS) is a widespread pain condition associated with fatigue, cognitive
Michelle J Ormseth +3 more
doaj
Pharmacotherapy for Fibromyalgia
Fibromyalgia (FM) is a chronic disorder characterized by multifocal pain and other associated somatic symptoms including fatigue, insomnia, cognitive/memory problems, and even psychological distress.
Howard eSmith +2 more
doaj +1 more source
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Milnacipran: a unique antidepressant?
Siegfried Kasper, Gerald PailDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, AustriaAbstract: Tricyclic antidepressants (TCAs) are among the most effective antidepressants available, although their poor tolerance at usual ...
Siegfried Kasper, Gerald Pail
doaj
Objective Abnormalities in pain regulatory mechanisms are common in patients with rheumatoid arthritis (RA). We investigated whether pain sensitization changes after treatment with a disease‐modifying antirheumatic drug (DMARD) and explored associations between changes in pain sensitization and disease activity.
Burcu Aydemir +10 more
wiley +1 more source

