Results 41 to 50 of about 3,621 (185)

Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters

Nature Communications, 2021
The Drosophila dopamine transporter (dDAT) is a catecholamine neurotransmitter transporter that resembles the human norepinephrine transporter (hNET). Here the authors report X-ray structures of the dDAT in substrate-free form, norepinephrine-bound form ...
Shabareesh Pidathala, Aditya Kumar Mallela, Deepthi Joseph, Aravind Penmatsa   +3 more
doaj   +1 more source

Current pharmacological treatment of fibromyalgia- a literature review

European Psychiatry, 2021
Introduction Fibromyalgia is a chronic condition, with a high degree of psychiatric comorbidity and an insufficiently explained pathogenesis. Therefore, its therapeutic management is challenging, with both pharmacological and non-pharmacological ...
O. Vasiliu
doaj   +1 more source

Utility of the chromogenic and fluorogenic properties of benzofurazan for the assay of milnacipran in human urine and plasma

RSC Advances, 2018
Our article presents the development and validation of two simple, very sensitive, and low-cost spectroscopic methods for the assay of milnacipran hydrochloride in bulk form, pharmaceutical tablets and spiked human urine and plasma. Spectroscopic methods
Islam M. Mostafa, Mahmoud A Omar, Dalia M. Nagy, S. Derayea   +3 more
semanticscholar   +1 more source

Milnacipran and venlafaxine at flexible doses (up to 200 mg/day) in the outpatient treatment of adults with moderate-to-severe major depressive disorder: a 24-week randomized, double-blind exploratory study

Neuropsychiatric Disease and Treatment, 2010
Jean-Pierre Olié1, David Gourion2, Agnès Montagne3, Michel Rostin4, Marie-France Poirier11Service de Santé Mentale et Thérapeutique, Centre Hospitalier Sainte-Anne, Paris, France; 217 rue des Marronniers, 75016
Jean-Pierre Olié, David Gourion, Agnès Montagne, et al   +3 more
doaj  

Delphi Consensus Among French Obesity Experts on Clinical Recommendations for Drug Prescription in Patients With Severe Obesity

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Introduction Although the physiologic alterations seen in obesity often affect the pharmacokinetics and pharmacodynamics of drugs, most clinical trials do not consider these aspects specifically for this population. To date, there is no list of potentially inappropriate medications for patients living with obesity. The aim of this study was to
Sarah Berdot, Germain Perrin, Emmanuel Disse, Armelle Arnoux, Eric Bertin, Anne‐Laure Borel, Marie‐Claude Brindisi, Arnaud De Luca, Edouard‐Jules Laforgue, Jean‐Daniel Lalau, Yann Matussiere, Emilie Montastier, Agnès Sallé, Bérénice Segrestin, Valentine Suteau, French Hospital Expert Panel, Sebastien Czernichow, Brigitte Sabatier   +17 more
wiley   +1 more source

Effect of milnacipran on body weight in patients with fibromyalgia

International Journal of General Medicine, 2012
Lesley M Arnold,1 Robert H Palmer,2 Michael R Hufford,3 Wei Chen21Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, 2Medical Affairs, Forest Research Institute Inc, Jersey City, NJ ...
Arnold LM, Palmer RH, Hufford MR, Chen W
doaj  

Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats.

Biological and Pharmaceutical Bulletin, 2018
Biological rhythms are thought to be related to the pathogenesis and therapy of various diseases including depression. Here we investigated the influence of circadian rhythms on the antidepressant activity of the dual-action serotonin-noradrenaline ...
H. Kawai, Megumi Machida, Takuya Ishibashi, N. Kudo, Y. Kawashima, A. Mitsumoto   +5 more
semanticscholar   +1 more source

Visualizing Real‐World Pain Treatment Pathways in Chronic Disease: A Sequence‐Based Analysis of Polypharmacy in Systemic Lupus Erythematosus

ACR Open Rheumatology, Volume 7, Issue 11, November 2025.
Objective To examine real‐world patterns in pain management among adults with systemic lupus erythematosus (SLE), we focused on the sequencing of pain modalities, polypharmacy, and demographic variation. Methods We conducted a retrospective analysis of electronic health records from adults with SLE treated at a single academic medical center between ...
Nathan Le, Martha O. Kenney, Andrew Walker, Tricia Park, Yashaar Chaichian, Michael H. Weisman, Anushka Irani, Selen Bozkurt, Titilola Falasinnu   +8 more
wiley   +1 more source

Current therapy of fibromyalgia syndrome

Современная ревматология, 2014
The data on pathogenetically significant parameters that are involved in pain perception in fibromyalgia (FM) patients (increased sensitivity or density of dopamine receptors D2, enhanced pain signal due to the elevated substance P level or insufficient ...
N.V. Chichasova, E.V. Igolkina
doaj   +3 more sources

Effects of Outdoor Therapy on Delirium in Patients With Prolonged Intensive Care Unit Stays: A Single‐Centre Retrospective Study

Nursing in Critical Care, Volume 30, Issue 6, November 2025.
ABSTRACT Background Delirium commonly occurs during prolonged intensive care unit (ICU) stays, yet the clinical benefit of escorted outdoor exposure for critically ill adults remains uncertain. Aim The aim of this study was to determine whether supervised outdoor therapy is associated with reduced delirium severity among adults with ICU stays ≥ 7 days.
Daichi Tsukakoshi, Hitoshi Mutai, Shuhei Yamamoto, Masaaki Sato, Keisuke Furuhashi, Toshinori Nakamura, Takashi Ichiyama, Hiroshi Imamura, Hiroshi Horiuchi   +8 more
wiley   +1 more source