Results 31 to 40 of about 263,258 (175)

A Higher-Order Formulation of the Mimetic Finite Difference Method

SIAM Journal on Scientific Computing, 2008
A new mimetic finite difference method for the diffusion problem is developed by using a linear interpolation for the numerical fluxes. This approach provides a higher-order accurate approximation to the flux of the exact solution. In analogy with the original formulation, a family of local scalar products is constructed to satisfy the fundamental ...
L. Beirao da Veiga, G. Manzini
openaire   +3 more sources

A Hybrid High-Order method for Leray-Lions elliptic equations on general meshes

, 2016
In this work, we develop and analyze a Hybrid High-Order (HHO) method for steady non-linear Leray-Lions problems. The proposed method has several assets, including the support for arbitrary approximation orders and general polytopal meshes.
Di Pietro, Daniele A., Droniou, Jérôme
core   +4 more sources

Enforcing the non-negativity constraint and maximum principles for diffusion with decay on general computational grids [PDF]

, 2010
In this paper, we consider anisotropic diffusion with decay, and the diffusivity coefficient to be a second-order symmetric and positive definite tensor.
Arnold, Barber, Boyd, Braess, Brezzi, Brezzi, Brezzi, Brezzi, Brezzi, Brezzi, Burman, Chadwick, Christie, Ciarlet, Ciarlet, Droniou, Eigestad, Fraenkel, Gilbarg, Herrera, Hughes, Hughes, Hyman, Höhn, Karnadakis, Karátson, Karátson, Keilegavlen, Korotov, Kuzmin, Kuznetsov, Ladyzhenskaya, Le Potier, Lipnikov, Lipnikov, Lipnikov, Liska, Luenberger, Masud, McOwen, Mlacnik, Morton, Nakshatrala, Nakshatrala, Nedelec, Nedelec, Nocedal, Nordbotten, Patankar, Protter, Pucci, Quarteroni, Raviart, Saad, Shashkov, Shewchuk, Strikwerda, Tikhonov, Trudinger, Vanselow, Varga, Varga, Vejchodsky, Yanik, Yanik, Yuan   +65 more
core   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Staggered grids discretization in three-dimensional Darcy convection

, 2008
We consider three-dimensional convection of an incompressible fluid saturated in a parallelepiped with a porous medium. A mimetic finite-difference scheme for the Darcy convection problem in the primitive variables is developed.
A.D. Nemtsev, Arakawa, B. Karasözen, Chorin, Govorukhin, Govorukhin, Ham, Hyman, Hyman, Kantur, Karasözen, Karasözen, Karasözen, Lyubimov, Morinishi, Nield, Straus, V.G. Tsybulin, Vasilyev, Vladimirova, Yudovich, Yudovich, Yudovich   +22 more
core   +1 more source

A Stress/Displacement Virtual Element Method for Plane Elasticity Problems

, 2017
The numerical approximation of 2D elasticity problems is considered, in the framework of the small strain theory and in connection with the mixed Hellinger-Reissner variational formulation. A low-order Virtual Element Method (VEM) with a-priori symmetric
Artioli, E., de Miranda, S., Lovadina, C., Patruno, L.   +3 more
core   +1 more source

All‐in‐One Underwater Quality Evaluation Metamaterial With Mechanical Robustness, Sound Attenuation, and Diffuse Reflection

Advanced Science, EarlyView.
In this work, a bioinspired all‐in‐one underwater quality evaluation metamaterial, combining sound attenuation, diffuse reflection, and mechanical robustness, is proposed based on jumping spider locomotion and human skeletal biomechanics. Meanwhile, a CNN‑driven quality evaluation framework is established for theoretically dimension‐reduced ...
Hongze Li, Zhenyu Li, Jinshui Yang, Jianhao Wu, Yidan Chen, Linzhi Wu, Hong Hu, Penglin Gao, Yegao Qu   +8 more
wiley   +1 more source

Optical diffraction for measurements of nano-mechanical bending [PDF]

, 2015
Micromechanical transducers such as cantilevers for AFM often rely on optical readout methods that require illumination of a specific region of the microstructure.
Aeppli, Gabriel, Dueck, Benjamin, Hermans, Rodolfo I., McKendry, Rachel A., Ndieyira, Joseph Wafula   +4 more
core   +2 more sources

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Conforming and nonconforming virtual element methods for elliptic problems

, 2015
We present in a unified framework new conforming and nonconforming Virtual Element Methods (VEM) for general second order elliptic problems in two and three dimensions.
Cangiani, Andrea, Manzini, Gianmarco, Sutton, Oliver J.   +2 more
core   +1 more source