Results 191 to 200 of about 125,939 (330)

Peptide Drugs in Gastrointestinal Tumors: Integrating Targeting, Delivery, and Therapeutic Actions for Synergistic Strategies. [PDF]

Biomolecules
Ouyang Q, Wu G, Chen A, Zhang R, Xiao S, Guo D, Zhang Q, Yan C, Chen XZ, Tang J, Lyu H.   +10 more
europepmc   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

Precision-Engineered Dermatan Sulfate-Mimetic Glycopolymers for Multi-Targeted SARS-CoV-2 Inhibition. [PDF]

Mar Drugs
Wang L, Gao L, Yang C, Yin M, Sun J, Yang L, Liu C, Hinkley SFR, Yu G, Cai C.   +9 more
europepmc   +1 more source

Mimetic fractional step methods for parabolic problems

, 2011
La presente memoria se enmarca en el ámbito de la resolución numérica de ecuaciones en derivadas parciales evolutivas de tipo parabólico. Este tipo de ecuaciones está involucrado en la modelización de una gran variedad de fenómenos físicos provenientes de diversos campos de la ciencia y la ingeniería.
openaire   +2 more sources

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Resveratrol Mimics Exercise-Induced Metabolic Stress to Suppress CIP2A and Epithelial-Mesenchymal Transition in 3D Renal Carcinoma Spheroids. [PDF]

Biomedicines
Lee BS, Kim JS, So WY.
europepmc   +1 more source

Supplementary Methods, Figures 1-12 from LRIG1 Modulates Cancer Cell Sensitivity to Smac Mimetics by Regulating TNFα Expression and Receptor Tyrosine Kinase Signaling

, 2023
Longchuan Bai, Donna McEachern, Chao‐Yie Yang, Jianfeng Lü, Haiying Sun, Shaomeng Wang   +5 more
openalex   +2 more sources

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

A shared gene but distinct dynamics regulate mimicry polymorphisms in closely related butterfly species. [PDF]

Proc Biol Sci
Sheikh SI, Doellman MM, VanKuren NW, Hall P, Kronforst MR.   +4 more
europepmc   +1 more source

Bone mimetic resorption plates: A reliable method to quantify osteoclast resorption in vitro

Christopher Grieg, Maya Deza Culbertson, J. Patrick O’Connor   +2 more
openalex   +1 more source