Results 281 to 290 of about 125,939 (330)

Stimuli‐Responsive Silsesquioxane Nanozymes for Organocatalysis in Water and Prodrug Activation in Cells

open access: yesAngewandte Chemie, EarlyView.
Amino‐bearing silsesquioxanes are water‐stable nanozymes that exhibit aggregation‐ and disaggregation‐dependent catalysis and can be applied to intracellular prodrug activation for cancer therapy. ABSTRACT Synthetic nanozymes have emerged as promising alternatives to natural enzymes for catalytic and therapeutic applications, yet their limited ...
Rabia Zahid   +4 more
wiley   +1 more source

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

open access: yesAngewandte Chemie International Edition, EarlyView.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran   +11 more
wiley   +1 more source

Cryo-EM structure of the tissue factor/factor VIIa complex with a factor X mimetic reveals a novel allosteric mechanism. [PDF]

open access: yesBlood
Sedzro JC   +11 more
europepmc   +1 more source

2.5-Dimensional Structure Approach for Miniaturizing Flapping-Wing Air Vehicles. [PDF]

open access: yesMicromachines (Basel)
Ishihara D   +9 more
europepmc   +1 more source

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