Results 111 to 120 of about 478,647 (296)

Taxation and employability in MIMIC [PDF]

open access: yes, 1999
CPB’s applied general equilibrium model for the Dutch economy, MIMIC, has recently been extended to include the effects of taxation on training incentives. This paper elaborates on the training model.
Mooij, R.A. (Ruud) de
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Does response scaling cause the Generalized Context Model to mimic a prototype model?

open access: yes, 2019
Smith and Minda (1998, 2002) argued that the response scaling parameter γ in the exemplar-based generalized context model (GCM) makes the model unnecessarily complex and allows it to mimic the behavior of a prototype model. We evaluated this criticism in
Mark Pitt   +2 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

A peak-oriented diffusion model for high-fidelity electrocardiogram reconstruction from photoplethysmogram: development and usability study

open access: yesBioData Mining
Background Cardiovascular disease is a leading cause of death, accounting for nearly one-third of all fatalities worldwide. The electrocardiogram (ECG), an electrophysiological signal representing cardiac activity, is a widely used non-invasive method ...
Hyun-Myung Cho   +3 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Extension of an ICU-based noninvasive model to predict latent shock in the emergency department: an exploratory study

open access: yesFrontiers in Cardiovascular Medicine
BackgroundArtificial intelligence (AI) has been widely adopted for the prediction of latent shock occurrence in critically ill patients in intensive care units (ICUs).
Mingzheng Wu   +6 more
doaj   +1 more source

A Bayesian MIMIC Model for Testing Non-uniform DIF in Two and Three Groups [PDF]

open access: yes, 2015
Multiple-indicator multiple cause (MIMIC) models have become a popular latent variable method to detect differential item functioning (DIF) by practitioners.
Harpole, Jared Kenneth
core  

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