Results 51 to 60 of about 1,063,820 (299)

miR-103 Promotes Neurite Outgrowth and Suppresses Cells Apoptosis by Targeting Prostaglandin-Endoperoxide Synthase 2 in Cellular Models of Alzheimer’s Disease

open access: yesFrontiers in Cellular Neuroscience, 2018
miR-103 has been reported to be decreased in brain of transgenic mouse model of Alzheimer’s disease (AD) and in cerebrospinal fluid (CSF) of AD patients, while the detailed mechanism of its effect on AD is obscure, thus this study aimed to investigate ...
Hui Yang   +3 more
doaj   +1 more source

The multiple indicator multiple cause model for cognitive neuroscience: An analytic tool which emphasizes the behavior in brain–behavior relationships

open access: yesFrontiers in Psychology, 2022
Cognitive neuroscience has inspired a number of methodological advances to extract the highest signal-to-noise ratio from neuroimaging data. Popular techniques used to summarize behavioral data include sum-scores and item response theory (IRT).
Adon F. G. Rosen   +6 more
doaj   +1 more source

Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells [PDF]

open access: yes, 2019
The gingival epithelium is a physical and immunological barrier to the microbiota of the oral cavity, which interact through soluble mediators with the immune cells that patrol the tissue at the gingival epithelium.
Bradshaw, David   +8 more
core   +4 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

The Health Literacy Instruments for Adults (HELIA): Comparison of the Multiple Indicators Multiple Causes (MIMIC) Model and Multi-Group Confirmatory Factor Analysis (MG-CFA) [PDF]

open access: yesPayesh
Objective(s): Currently there are various methods to analyze Differential Item Functioning(DIF) and to evaluate the similarity of people's understanding of a questionnaire’s items in different subgroups, among them are the Multi-Group Confirmatory Factor
Farideh Khosravi, Jamshid Jamali
doaj  

Quantum billiards in multidimensional models with branes [PDF]

open access: yes, 2014
Gravitational D-dimensional model with l scalar fields and several forms is considered. When cosmological type diagonal metric is chosen, an electromagnetic composite brane ansatz is adopted and certain restrictions on the branes are imposed the ...
Ivashchuk, V. D., Melnikov, V. N.
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Comment on "Spin-1 aggregation model in one dimension"

open access: yes, 2001
M. Girardi and W. Figueiredo have proposed a simple model of aggregation in one dimension to mimic the self-assembly of amphiphiles in aqueous solution [Phys. Rev. E 62, 8344 (2000)].
D. Duque   +6 more
core   +1 more source

Composite dark energy: cosmon models with running cosmological term and gravitational coupling [PDF]

open access: yes, 2006
In the recent literature on dark energy (DE) model building we have learnt that cosmologies with variable cosmological parameters can mimic more traditional DE pictures exclusively based on scalar fields (e.g. quintessence and phantom).
Amendola   +65 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

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