Results 61 to 70 of about 478,647 (296)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

miR-103 Promotes Neurite Outgrowth and Suppresses Cells Apoptosis by Targeting Prostaglandin-Endoperoxide Synthase 2 in Cellular Models of Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2018
miR-103 has been reported to be decreased in brain of transgenic mouse model of Alzheimer’s disease (AD) and in cerebrospinal fluid (CSF) of AD patients, while the detailed mechanism of its effect on AD is obscure, thus this study aimed to investigate ...
Hui Yang, Hongcai Wang, Yongwei Shu, Xuling Li   +3 more
doaj   +1 more source

A generalizable and interpretable model for mortality risk stratification of sepsis patients in intensive care unit

BMC Medical Informatics and Decision Making, 2023
Purpose This study aimed to construct a mortality model for the risk stratification of intensive care unit (ICU) patients with sepsis by applying a machine learning algorithm.
Jinhu Zhuang, Haofan Huang, Song Jiang, Jianwen Liang, Yong Liu, Xiaxia Yu   +5 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Predicting acute kidney injury risk in acute myocardial infarction patients: An artificial intelligence model using medical information mart for intensive care databases

Frontiers in Cardiovascular Medicine, 2022
BackgroundPredictive models based on machine learning have been widely used in clinical practice. Patients with acute myocardial infarction (AMI) are prone to the risk of acute kidney injury (AKI), which results in a poor prognosis for the patient.
Dabei Cai, Dabei Cai, Tingting Xiao, Ailin Zou, Lipeng Mao, Lipeng Mao, Boyu Chi, Boyu Chi, Yu Wang, Qingjie Wang, Qingjie Wang, Yuan Ji, Ling Sun, Ling Sun   +13 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

AN ANALYSIS OF THE SHADOW ECONOMY IN EU COUNTRIES [PDF]

CES Working Papers, 2016
The paper aims at analysing the dimension of the underground economy in the EU states between 2003 and 2015. In order to achieve this goal, we use qualitative and quantitative methods. In the first two sections of the study we resort to conceptualisation
Brindusa Mihaela Tudose, Raluca Irina Clipa   +1 more
doaj  

The multiple indicator multiple cause model for cognitive neuroscience: An analytic tool which emphasizes the behavior in brain–behavior relationships

Frontiers in Psychology, 2022
Cognitive neuroscience has inspired a number of methodological advances to extract the highest signal-to-noise ratio from neuroimaging data. Popular techniques used to summarize behavioral data include sum-scores and item response theory (IRT).
Adon F. G. Rosen, Emma Auger, Nicholas Woodruff, Alice Mado Proverbio, Hairong Song, Lauren E. Ethridge, David Bard   +6 more
doaj   +1 more source

Comparing MIMIC and MIMIC-interaction to Alignment Methods for Investigating Measurement Invariance concerning a Continuous Violator

, 2023
Measurement invariance holds when a latent construct is measured in the same way across different levels of background variables (continuous or categorical) while controlling for the true value of that construct.
Mark H. C. Lai (3308694), Yuanfang Liu (1841497), Ben Kelcey (17048811)   +2 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source