Results 51 to 60 of about 15,026,011 (256)
Frontiers in Cellular Neuroscience, 2018 miR-103 has been reported to be decreased in brain of transgenic mouse model of Alzheimer’s disease (AD) and in cerebrospinal fluid (CSF) of AD patients, while the detailed mechanism of its effect on AD is obscure, thus this study aimed to investigate ...
Hui Yang +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
BMC Medical Informatics and Decision Making, 2023 Purpose This study aimed to construct a mortality model for the risk stratification of intensive care unit (ICU) patients with sepsis by applying a machine learning algorithm.
Jinhu Zhuang +5 more
doaj +1 more source
WP4: Smart Governance. Deliverable 4.3: Policy instrument [PDF]
, 2021 Preface. This report is a deliverable (D4.3) in the MIMIC project, under WP4, Task 4.3. The aim of WP4 is: • test the Smart Governance Concept 1.0 developed under the previous CIVIC project with an attempt to include construction logistics planning in
Brusselaers, Nicolas +6 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
MIMIC model estimates exploring relations to other variables (n = 516).
, 2022 MIMIC model estimates exploring relations to other variables (n = 516).
Brooke Linden (13013525) +1 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
AN ANALYSIS OF THE SHADOW ECONOMY IN EU COUNTRIES [PDF]
CES Working Papers, 2016 The paper aims at analysing the dimension of the underground economy in the EU states between 2003 and 2015. In order to achieve this goal, we use qualitative and quantitative methods. In the first two sections of the study we resort to conceptualisation
Brindusa Mihaela Tudose +1 more
doaj
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Cross-cultural adaptation and factor structure investigation of the Marital Forgiveness Scale
Psikohumaniora: Jurnal Penelitian PsikologiForgiveness is essential in marriage as it can bring a sense of satisfaction to married life. This study aims to adapt and examine the factor structure of the Marital Forgiveness Scale (MFS), a forgiveness instrument in the context of marriage. After the
Endah Puspita Sari +2 more
doaj +1 more source