Results 51 to 60 of about 478,647 (296)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
TruthfulQA: Measuring How Models Mimic Human Falsehoods
Proceedings of the 60th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), 2022 ACL 2022 (main conference); the TruthfulQA benchmark and evaluation code is available at https://github.com/sylinrl ...
Stephanie Lin, Jacob Hilton, Owain Evans
openaire +2 more sources
Ruthenium porphyrin-ß-cyclodextrin complexes as supramolecular enzyme models for regioselective cleavage of carotenoids [PDF]
, 2006 All naturally occurring vitamin A derives from enzymatic oxidative cleavage of β,β-carotene or other carotenoids with pro-vitamin A activity. Two metabolic pathways of β,β-carotene to retinal (vitamin A aldehyde) have been proposed: the central cleavage ...
Wang, Hao
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Health Literacy Instruments for Adults (HELIA): Comparison of the Multiple Indicators Multiple Causes (MIMIC) Model and Multi-Group Confirmatory Factor Analysis (MG-CFA) [PDF]
PayeshObjective(s): Currently there are various methods to analyze Differential Item Functioning(DIF) and to evaluate the similarity of people's understanding of a questionnaire’s items in different subgroups, among them are the Multi-Group Confirmatory Factor
Farideh Khosravi, Jamshid Jamali
doaj
The effects of floral mimics and models on each others' fitness [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2006 Plants that lack floral rewards may nevertheless attract pollinators by mimicking the flowers of rewarding plants. It has been suggested that both mimics and models should suffer reduced fitness when mimics are abundant relative to their models.
Bruce, Anderson, Steven D, Johnson
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source