Results 81 to 90 of about 15,026,011 (256)

Evaluation of mimic defense strategy based on M-FlipIt game model

open access: yesTongxin xuebao, 2020
To make up for the lack of security performance evaluation of the mimic defense systems in the advanced persistent threat scenarios an improved game model based on the FlipIt game theory model was proposed.The dynamic strategy of mimic defense under ...
Shaohu DING, Ning QI, Yiwei GUO
doaj   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

The MIMIC–CUB Model for the Prediction of the Economic Public Opinions in Europe [PDF]

open access: yes, 2018
To study the Europeans’ perception on the economic conditions, a model that combine Multiple Indicators Multiple Causes (MIMIC) and Combination of Uniform and shifted Binomial (CUB) is proposed.
Mariangela Nitti   +5 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Preparation of Model Surfaces to Mimic Porous Cellulose Structures

open access: yesAdvanced Materials Interfaces
Porous cellulose and nanocellulose materials, such as foams and aerogels, are widely used in numerous applications due to their large surface area, sorption capacity, mechanical resilience, and overall versatility.
Tiinamari Seppänen   +4 more
doaj   +1 more source

Measuring the Role of Observable Variables of Student Engagement on College Belongingness Using the MIMIC Model

open access: yesGadjah Mada Journal of Psychology
Online learning due to social restrictions that occurred during the COVID-19 pandemic reduced student engagement in both academic and non-academic fields, which was followed by a decline in college belongingness. However, student engagement takes various
Sayang Ajeng Mardhiyah   +2 more
doaj   +1 more source

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