Results 81 to 90 of about 444,284 (257)
BMC Medical Research Methodology, 2020 Background The multiple-indicator, multiple-cause model (MIMIC) incorporates covariates of interest in the factor analysis. It is a special case of structural equation modeling (SEM), which is modeled under latent variable framework.
Chi Chang +3 more
doaj +1 more source
An Animal Model That Mimics Human Herpesvirus 6B Pathogenesis
Journal of Virology, 2020 Human herpesvirus 6B (HHV-6B) is a ubiquitous virus that establishes lifelong latent infection only in humans, and the infection can reactivate, with severe complications that cause major problems. A small-animal model of HHV-6B infection has thus been desired for research regarding the pathogenicity of HHV-6B and the development of ...
Bochao, Wang +11 more
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Evaluation of mimic defense strategy based on M-FlipIt game model
Tongxin xuebao, 2020 To make up for the lack of security performance evaluation of the mimic defense systems in the advanced persistent threat scenarios an improved game model based on the FlipIt game theory model was proposed.The dynamic strategy of mimic defense under ...
Shaohu DING, Ning QI, Yiwei GUO
doaj +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Variable Selection in Structural Equation Models with Regularized MIMIC Models
, 2018 Methodological innovations have allowed researchers to consider increasingly sophisticated statistical models that are better in line with the complexities of real world behavioural data. However, despite these powerful new analytic approaches, sample sizes may not always be sufficiently large to deal with the increase in model complexity. This poses a
Ross Jacobucci +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Catalytic, theoretical, and biological investigation of an enzyme mimic model. [PDF]
Turk J Chem, 2021 Gülseren G.
europepmc +1 more source