As a local breed adapted to the extreme environment of the Tibetan Plateau, Tibetan pigs have not yet been systematically characterized in terms of their gut viral communities. In this study, we applied viral metagenomics to sequence fecal samples from 191 Tibetan pigs (including both healthy and diarrheal individuals) across four farms in Nyingchi ...
Jiaheng Chen +11 more
wiley +1 more source
Lausannevirus Seroprevalence among Asymptomatic Young Adults. [PDF]
Objectives: The giant Lausannevirus was recently identified as a parasite of amoeba that replicates rapidly in these professional phagocytes. This study aimed at assessing Lausannevirus seroprevalence among asymptomatic young men in Switzerland and ...
Baud, D. +3 more
core +1 more source
The effects of stress on gut virome: Implications on infectious disease and systemic disorders
Stress conditions can weaken the host's immune system, affecting the entire gut–brain axis. Concurrently, disruptions in the composition of the gut microbiota are associated with exacerbations of diseases. This review explores the complex interplay between stress, gut virome, and the host immune system.
Francesca Talarico +5 more
wiley +1 more source
Our comparative analysis unveiled the distinct advantages of two methods in capturing the complexity of viral communities and their functions in wastewater treatment plants. The non‐concentrated (NC) metagenomic approach identified a higher number of viral contigs, though it had a lower yield of high‐quality contigs.
Jiayu Zhang +10 more
wiley +1 more source
Lausannevirus Encodes a Functional Dihydrofolate Reductase Susceptible to Proguanil. [PDF]
Lausannevirus belongs to the family Marseilleviridae within the group of nucleocytoplasmic large DNA viruses (NCLDVs). These giant viruses exhibit unique features, including a large genome, ranging from 100 kb to 2.5 Mb and including from 150 to more ...
Gauye, F. +3 more
core +1 more source
Dinucleotide biases in the genomes of prokaryotic and eukaryotic dsDNA viruses and their hosts
Abstract The genomes of cellular organisms display CpG and TpA dinucleotide composition biases. Such biases have been poorly investigated in dsDNA viruses. Here, we show that in dsDNA virus, bacterial, and eukaryotic genomes, the representation of TpA and CpG dinucleotides is strongly dependent on genomic G + C content.
Diego Forni +3 more
wiley +1 more source
Evolution of DNA ligases of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes: a case of hidden complexity [PDF]
Background Eukaryotic Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) encode most if not all of the enzymes involved in their DNA replication. It has been inferred that genes for these enzymes were already present in the last common ancestor of the NCLDV ...
Koonin Eugene V, Yutin Natalya
core +1 more source
Phaeocystis globosa Virus DNA Polymerase X: a “Swiss Army knife”, Multifunctional DNA polymerase-lyase-ligase for Base Excision Repair [PDF]
Phaeocystis globosa virus 16T is a giant virus that belongs to the so-called nucleo-cytoplasmic large DNA virus (NCLDV) group. Its linear dsDNA genome contains an almost full complement of genes required to participate in viral base excision repair (BER).
Fernández-García, J.L. +3 more
core +4 more sources
The gut virome:the ‘missing link’ between gut bacteria and host immunity? [PDF]
The human gut virome includes a diverse collection of viruses that infect our own cells as well as other commensal organisms, directly impacting on our well-being. Despite its predominance, the virome remains one of the least understood components of the
Carding, Simon R. +4 more
core +2 more sources
Biogeography of marine giant viruses reveals their interplay with eukaryotes and ecological functions [PDF]
海洋巨大ウイルスの地理的分布を全球規模で解明 --海域による特異性が明らかに--. 京都大学プレスリリース. 2020-09-08.Nucleocytoplasmic large DNA viruses (NCLDVs) are ubiquitous in marine environments and infect diverse eukaryotes. However, little is known about their biogeography and ecology in the ocean.
Blanc-Mathieu, Romain +12 more
core +2 more sources

