Results 51 to 60 of about 4,249 (213)

Exploring ORFan domains in giant viruses: structure of mimivirus sulfhydryl oxidase R596. [PDF]

PLoS ONE, 2012
The mimivirus genome contains many genes that lack homologs in the sequence database and are thus known as ORFans. In addition, mimivirus genes that encode proteins belonging to known fold families are in some cases fused to domain-sized segments that ...
Motti Hakim, Daria Ezerina, Assaf Alon, Ohad Vonshak, Deborah Fass   +4 more
doaj   +1 more source

Microscopic Characterization of the Brazilian Giant Samba Virus

Viruses, 2017
Prior to the discovery of the mimivirus in 2003, viruses were thought to be physically small and genetically simple. Mimivirus, with its ~750-nm particle size and its ~1.2-Mbp genome, shattered these notions and changed what it meant to be a virus. Since
Jason R. Schrad, Eric J. Young, Jônatas S. Abrahão, Juliana R. Cortines, Kristin N. Parent   +4 more
doaj   +1 more source

Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes [PDF]

, 2013
Nucleo-cytoplasmic large DNA viruses (NCLDVs) constitute a group of eukaryotic viruses that can have crucial ecological roles in the sea by accelerating the turnover of their unicellular hosts or by causing diseases in animals. To better characterize the
Acinas, Silvia G., Bork, Peer, Claverie, Jean-Michel, Clerissi, Camille, de Vargas, Colomban, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Desdevises, Yves, Faust, Karoline, Ferrera, Isabel, Grimsley, Nigel, Hingamp, Pascal, Jaillon, Olivier, Kandels-Lewis, Stefanie, Karsenti, Eric, Lima-Medez, Gipsi, Moreau, Hervé, Not, Fabrice, Ogata, Hiroyuki, Pesant, Stéphane, Poulain, Julie, Raes, Jeroen, Sarmento, Hugo, Subirana, Lucie, Sunagawa, Shinichi, Villar, Emilie, Wincker, Patrick   +27 more
core   +1 more source

Characterization of an aminotransferase from Acanthamoeba polyphaga Mimivirus

Protein Science, 2021
Acanthamoeba polyphaga Mimivirus, a complex virus that infects amoeba, was first reported in 2003. It is now known that its DNA genome encodes for nearly 1,000 proteins including enzymes that are required for the biosynthesis of the unusual sugar 4‐amino‐
C. A. Seltzner, J. D. Ferek, J. Thoden, H. Holden   +3 more
semanticscholar   +1 more source

Generation of Infectious Mimivirus Virions Through Inoculation of Viral DNA Within Acanthamoeba castellanii Shows Involvement of Five Proteins, Essentially Uncharacterized

Frontiers in Microbiology, 2021
One of the most curious findings associated with the discovery of Acanthamoeba polyphaga mimivirus (APMV) was the presence of many proteins and RNAs within the virion. Although some hypotheses on their role in Acanthamoeba infection have been put forward,
D. Sahmi-Bounsiar, J. Baudoin, Sihem Hannat, P. Decloquement, Eric Chabrières, S. Aherfi, B. La Scola   +6 more
semanticscholar   +1 more source

O-Linked glycosylation in Acanthamoeba polyphaga mimivirus [PDF]

Glycobiology, 2014
Acanthamoeba polyphaga mimivirus is a member of the giant nucleocytoplasmic large DNA viruses, infecting various Acanthamoeba spp. The genomes of giant viruses encode components previously thought to be exclusive to cellular life, such as proteins involved in nucleic acid and protein synthesis.
Hulsmeier A. J., Hennet T.
openaire   +4 more sources

Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser [PDF]

, 2016
Citation: Ekeberg, T., Svenda, M., Seibert, M. M., Abergel, C., Maia, F. R. N. C., Seltzer, V., . . . Hajdu, J. (2016). Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser. Scientific Data, 3.
Abergel, C., Andersson, I., Andreasson, J., Aquila, A., Bajt, S., Barthelmess, M., Barty, A., Bogan, M. J., Bostedt, C., Bozek, J. D., Chapman, H., Claverie, J. M., Coppola, N., DePonte, D. P., Ekeberg, T., Epp, S. W., Erk, B., Fleckenstein, H., Foucar, L., Frank, M., Graafsma, H., Gumprecht, L., Hajdu, J., Hampton, C. Y., Hartmann, A., Hartmann, R., Hauser, G., Hirsemann, H., Holl, P., Iwan, B., Jonsson, O., Kassemeyer, S., Kimmel, N., Krasniqi, F., Krzywinski, J., Liang, M., Loh, N. D., Lomb, L., Maia, F. R. N. C., Martin, A. V., Messerschmidt, M., Odic, D., Reich, C., Rolles, Daniel, Rudek, B., Rudenko, Artem, Schlichting, I., Schmidt, C., Schorb, S., Seibert, M. M., Seltzer, V., Shoeman, R. L., Sierra, R. G., Soltau, H., Struder, L., Svenda, M., Ullrich, J., Weidenspointner, G., Westphal, D., Wunderer, C.   +59 more
core   +2 more sources

Paving the way towards understanding the inflammatory pathways triggered by giant viruses in mammalian cells: effect of mimivirus-cell interactions on IκBα degradation

bioRxiv, 2021
Even after two decades since the identification of the first giant virus, the Acanthamoeba polyphaga mimivirus (APMV), it still elude scientists. Their gigantic size and genome are unique in the whole virosphere, and many aspects of their biology are ...
Juliana dos Santos Oliveira, D. F. Oliveira, Victor Alejandro Essus, Gabriel Henrique Pereira Nunes, L. Honorato, L. Oliveira, L. Nimrichter, J. M. Peralta, A. Guimarães, D. Foguel, J. Cortines   +10 more
semanticscholar   +1 more source

mRNA maturation in giant viruses: variation on a theme [PDF]

, 2015
International audienceGiant viruses from the Mimiviridae family replicate entirely in their host cytoplasm where their genes are transcribed by a viral transcription apparatus. mRNA polyadenylation uniquely occurs at hairpin-forming palindromic sequences
Abergel, Chantal, Claverie, Jean-Michel, Debart, Françoise, Lartigue, Audrey, Priet, Stéphane   +4 more
core   +4 more sources

Advances in Mimivirus Pathogenicity

Intervirology, 2010
Viral diseases in the clinical setting have been extensively investigated. Viruses are now considered as potentially responsible for nosocomial infections, especially in intensive care unit (ICU) patients. Mimivirus is the largest virus known to date.
Agnès, Vincent, Bernard, La Scola, Laurent, Papazian   +2 more
openaire   +2 more sources