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The inhibitory effect of mimosine on collagen synthesis
Toxicon, 1975Abstract The effect of mimosine [β-N(3-hydroxy-4-pyridone)-α-amino propionic acid] on the biosynthesis of collagen has been studied in embryonic cartilage. The synthesis of hydroxyproline-14C was markedly inhibited in the presence of 1 mM mimosine. Autoradiographs of embryonic cartilage indicated that when the hydroxylation of proline was inhibited ...
S Y, Tang, K H, Ling
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Mimosine Inhibits Viral DNA Synthesis through Ribonucleotide Reductase
Virology, 1994The plant amino acid mimosine (beta-N(3-hydroxy-4-pyridone)-alpha-amino propionic acid) is toxic for animals and reversibly inhibits the replication of animal cells in vitro. We have found that mimosine inhibits the DNA synthesis of a variety of DNA viruses, including adenovirus, parvovirus, and papovavirus and the replication of vaccinia and herpes ...
Y, Dai +3 more
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Biological Trace Element Research, 2007
During the growth of selenium (Se)-deficient seedlings of Vigna radiata, exposure to mimosine [2-amino-3-(3-hydroxy-4-oxo-1H-pyridin-1-yl)-propanoic acid], a nonprotein plant amino acid, effectively mitigated stress at 0.1 mM, as reflected in enhancement of growth and efficiency of mitochondrial functions. Since the changes in the seedlings elicited by
K, Lalitha, S R, Kulothungan
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During the growth of selenium (Se)-deficient seedlings of Vigna radiata, exposure to mimosine [2-amino-3-(3-hydroxy-4-oxo-1H-pyridin-1-yl)-propanoic acid], a nonprotein plant amino acid, effectively mitigated stress at 0.1 mM, as reflected in enhancement of growth and efficiency of mitochondrial functions. Since the changes in the seedlings elicited by
K, Lalitha, S R, Kulothungan
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G1/S Phase Synchronization Using Mimosine Arrest
Cold Spring Harbor Protocols, 2006INTRODUCTIONThis protocol uses the plant amino acid mimosine as a G1/S synchronizing agent. Cells are first treated with excess thymidine to accumulate the majority of them at G1/S; however, some cells will have stopped growth within the S phase. Thymidine is then removed to allow all the cells to proceed completely through the S phase.
Paul J, Galgano, Carl L, Schildkraut
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The Chemistry and Biological Activities of Mimosine: A Review
Phytotherapy Research, 2016Mimosine [β‐[N‐(3‐hydroxy‐4‐oxypyridyl)]‐α‐aminopropionic acid] is a non‐protein amino acid found in the members of Mimosoideae family. There are a considerable number of reports available on the chemistry, methods for estimation, biosynthesis, regulation, and degradation of this secondary metabolite.
Binh Cao Quan, Nguyen, Shinkichi, Tawata
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A rapid colorimetric method for the determination of mimosine
Archives of Biochemistry and Biophysics, 1951Abstract A rapid colorimetric method has been described for the quantitative determination of mimosine by using activated carbon as a decolorizing agent and measuring the intensity of mimosine-ferric chloride color produced.
H, MATSUMOTO, G D, SHERMAN
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Unbound and bound parameters of mimosine residue for Amber03 and Amber99sb forcefield in GROMACS ...
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Prenatal toxicity of L-mimosine in Wistar rats
ToxiconL-Mimosine is the main active component of the plant Leucaena leucocephala. Due to its metal-chelating mechanism, it interacts with various metabolic pathways in living organisms, making it a potential pharmacological target, although it also leads to toxicity.
Elaine R.M. de Almeida +5 more
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Mimosine’s Mechanism is Pyridoxal-Phosphate Independent
2000Mimosine is a toxic plant amino acid and a structural analog of both pyridoxal-phosphate (PLP) and tyrosine (figure 1)(1) Mimosine has been described as an effective inhibitor of DNA replication in mammalian cells(2), Several mechanisms have been proposed to explain mimosine’s inhibitory effects; but none have been reliably confirmed.
Emia Oppenheim, Patrick J. Stover
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American Journal of Ophthalmology, 1959
L, VON SALLMANN, P, GRIMES, E, COLLINS
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L, VON SALLMANN, P, GRIMES, E, COLLINS
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