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Effect of mimosine on the rat fetus
Teratology, 1970AbstractGroups of 16 pregnant rats per treatment were fed ad libitum a basal diet containing 0, 0.3, 0.5, or 0.7% mimosine or allowed a restricted intake of the diet with no mimosine until killed on day 20 of gestation.Incremental increases of mimosine caused significant (P<0.01) decreases in daily feed consumption, weight gain per unit of food, and
S, Dewreede, O, Wayman
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The Dual Effect of Mimosine on DNA Replication
Experimental Cell Research, 1997The plant amino acid, mimosine, is an extremely effective inhibitor of DNA replication in mammalian cells, but the mechanism by which this inhibition is achieved is unknown. The drug has been proposed either to inhibit initiation at origins of replication or to inhibit chain elongation by lowering nucleotide pool levels.
R F, Kalejta, J L, Hamlin
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Antitumor Activity of Mimosine and Mimosine HYdrochloride against B16 Melanoma in BDF Mice
1976Mimosine, β-N-(3-hydroxy-4-pyridone) α-aminopropionic acid, and its hydrochloride produced significant inhibition of subcutaneously transplanted murine B16 melanoma in BDF1 female mice. In such mice during mimosine treatment differences developed in the reactivity of both surface membrane and cytoplasmic antigens as compared to untreated cells.
T. A. Khwaja +2 more
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The inhibitory effect of mimosine on collagen synthesis
Toxicon, 1975Abstract The effect of mimosine [β-N(3-hydroxy-4-pyridone)-α-amino propionic acid] on the biosynthesis of collagen has been studied in embryonic cartilage. The synthesis of hydroxyproline-14C was markedly inhibited in the presence of 1 mM mimosine. Autoradiographs of embryonic cartilage indicated that when the hydroxylation of proline was inhibited ...
S Y, Tang, K H, Ling
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Mimosine Inhibits Viral DNA Synthesis through Ribonucleotide Reductase
Virology, 1994The plant amino acid mimosine (beta-N(3-hydroxy-4-pyridone)-alpha-amino propionic acid) is toxic for animals and reversibly inhibits the replication of animal cells in vitro. We have found that mimosine inhibits the DNA synthesis of a variety of DNA viruses, including adenovirus, parvovirus, and papovavirus and the replication of vaccinia and herpes ...
Y, Dai +3 more
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Biological Trace Element Research, 2007
During the growth of selenium (Se)-deficient seedlings of Vigna radiata, exposure to mimosine [2-amino-3-(3-hydroxy-4-oxo-1H-pyridin-1-yl)-propanoic acid], a nonprotein plant amino acid, effectively mitigated stress at 0.1 mM, as reflected in enhancement of growth and efficiency of mitochondrial functions. Since the changes in the seedlings elicited by
K, Lalitha, S R, Kulothungan
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During the growth of selenium (Se)-deficient seedlings of Vigna radiata, exposure to mimosine [2-amino-3-(3-hydroxy-4-oxo-1H-pyridin-1-yl)-propanoic acid], a nonprotein plant amino acid, effectively mitigated stress at 0.1 mM, as reflected in enhancement of growth and efficiency of mitochondrial functions. Since the changes in the seedlings elicited by
K, Lalitha, S R, Kulothungan
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G1/S Phase Synchronization Using Mimosine Arrest
Cold Spring Harbor Protocols, 2006INTRODUCTIONThis protocol uses the plant amino acid mimosine as a G1/S synchronizing agent. Cells are first treated with excess thymidine to accumulate the majority of them at G1/S; however, some cells will have stopped growth within the S phase. Thymidine is then removed to allow all the cells to proceed completely through the S phase.
Paul J, Galgano, Carl L, Schildkraut
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A rapid colorimetric method for the determination of mimosine
Archives of Biochemistry and Biophysics, 1951Abstract A rapid colorimetric method has been described for the quantitative determination of mimosine by using activated carbon as a decolorizing agent and measuring the intensity of mimosine-ferric chloride color produced.
H, MATSUMOTO, G D, SHERMAN
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Unbound and bound parameters of mimosine residue for Amber03 and Amber99sb forcefield in GROMACS ...
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Prenatal toxicity of L-mimosine in Wistar rats
ToxiconL-Mimosine is the main active component of the plant Leucaena leucocephala. Due to its metal-chelating mechanism, it interacts with various metabolic pathways in living organisms, making it a potential pharmacological target, although it also leads to toxicity.
Elaine R.M. de Almeida +5 more
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