Results 31 to 40 of about 1,606,010 (297)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Mind of a Mouse [PDF]

Cell, 2020
Large scientific projects in genomics and astronomy are influential not because they answer any single question but because they enable investigation of continuously arising new questions from the same data-rich sources. Advances in automated mapping of the brain's synaptic connections (connectomics) suggest that the complicated circuits underlying ...
Abbott, Larry F., Bock, Davi D., Callaway, Edward M., Denk, Winfried, Dulac, Catherine, Fairhall, Adrienne L., Fiete, Ila, Harris, Kristen M., Helmstaedter, Moritz, Jain, Viren, Kasthuri, Narayanan, LeCun, Yann, Lichtman, Jeff W., Littlewood, Peter B., Luo, Liqun, Maunsell, John H. R., Reid, R. Clay, Rosen, Bruce R., Rubin, Gerald M., Sejnowski, Terrence J., Seung, H. Sebastian, Svoboda, Karel, Tank, David W., Tsao, Doris Y., Van Essen, David C.   +24 more
openaire   +5 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

With Mind – into the Future.

Філософія освіти
Review of the monograph of the rector of the Dragomanov Ukrainian State University, Full Member (Academician) of the National Academy of Educational Sciences of Ukraine, Corresponding Member of the National Academy of Sciences of Ukraine, Doctor of ...
Надія Корабльова
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

THE PHILOSOPHY OF CONSCIOUSNESS WITHOUT AN OBJECT

Вісник НЮУ імені Ярослава Мудрого: Серія: Філософія, філософія права, політологія, соціологія
The philosophy of consciousness without an object represents a profound inquiry into the nature of consciousness when divorced from its typical objects of thought, perception, or attention. This paper examines the theoretical underpinnings, implications,
Khrystyna Khvoinytska-Pereima
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Unifying Opposites through Metaphor: A Cognitive Approach to the Buddhist Metaphors for the Mind in the Awakening of Faith Discourse

Religions, 2018
While metaphors for the human mind have been intensively discussed across multiple disciplines, there remains a gap on how Buddhism deals with the mind metaphorically. This study explores how Mahāyāna Buddhist discourse resorts to embodied and discursive
Byongchang Kang
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Developing a Formal Model for Mind Maps [PDF]

, 2011
Mind map is a graphical technique, which is used to represent words, concepts, tasks or other connected items or arranged around central topic or idea. Mind maps are widely used, therefore exist plenty of software programs to create or edit them, while ...
Siochos, Vasilis, Papatheodorou, Christos   +1 more
core   +1 more source