Results 41 to 50 of about 1,647,449 (247)
Філософія освітиReview of the monograph of the rector of the Dragomanov Ukrainian State University, Full Member (Academician) of the National Academy of Educational Sciences of Ukraine, Corresponding Member of the National Academy of Sciences of Ukraine, Doctor of ...
Надія Корабльова
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
THE PHILOSOPHY OF CONSCIOUSNESS WITHOUT AN OBJECT
Вісник НЮУ імені Ярослава Мудрого: Серія: Філософія, філософія права, політологія, соціологіяThe philosophy of consciousness without an object represents a profound inquiry into the nature of consciousness when divorced from its typical objects of thought, perception, or attention. This paper examines the theoretical underpinnings, implications,
Khrystyna Khvoinytska-Pereima
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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The dilemma of mind in contemporary Buddhism : some British testimony [PDF]
, 2006 Progress in neuroscience over the last half-century casts doubt on the religious intuition that the mind is a non-material entity. Without some dialogue between religion and science in order to resolve differences of fact and value, the dilemma of the ...
Kennedy, Andrew William
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Religions, 2018 While metaphors for the human mind have been intensively discussed across multiple disciplines, there remains a gap on how Buddhism deals with the mind metaphorically. This study explores how Mahāyāna Buddhist discourse resorts to embodied and discursive
Byongchang Kang
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
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Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
WHY A BRAIN CAPABLE OF LANGUAGE EVOLVED ONLY ONCE: PREFRONTAL CORTEX AND SYMBOL LEARNING
Zygon, 1996 . Language and information processes are critical issues in scientific controversies regarding the qualities that epitomize humanness. Whereas some theorists claim human mental uniqueness with regard to language, others point to successes in teaching ...
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