Results 91 to 100 of about 11,854 (255)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Research of Mine-used Digital Three-phase Power Supply

Gong-kuang zidonghua, 2012
For the problem of harmonic pollution of underground power network caused by existing mine-used three-phase power supply, a mine-used digital three-phase power supply based on STM32F103VB was designed and working principle and control strategies of the ...
YANG Jian-kang, SHEN Ya-rui, SONG Jian-cheng   +2 more
doaj  

Research and application of remote intelligent fluid supply and power supply technology in coal mine super-long strike fully mechanized caving face

Meitan kexue jishu
In the working conditions of long-strike coal mine faces, the traditional approach for liquid supply and power supply equipment is mobile withdrawal to follow the mining progress. However, this production method has several drawbacks. It involves a large
Chuanming ZHANG, Qingkai ZANG, Yongming NIU, Hui GUO, Ran LI, Dongyue ZHANG   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Simulation Research of Lightning of Mine Power Supply System

Gong-kuang zidonghua, 2010
The paper selected 110 kV transmission line of mine area for simulation research object and used ATP-EMTP electromagnetic transient analysis software to establish mathematical model of transmission line struck by lightning. It made simulation analysis for influence of lightning process by changing grounded resistance value of tower and installing or ...
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Uninterruptible power supply system for mining industry enterprises

Записки Горного института, 2018
Immediate problem of compensating falls and deviations of voltage in the power supply systems of mining enterprises in order to ensure the proper level of power supply reliability for the most important technological consumers is substantiated in the article.
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source