Results 51 to 60 of about 446,152 (228)

Reclamation activities at the Nickel Plate Mine

, 1994
Nickel Plate Mine is a 3 700 tonnes / day open pit gold mine located 45 kilometres west of Penticton. The mine is owned by Homestake Canada. During 1992 & 1993 the mine was able to demonstrate a number of progressive reclamation techniques.
Napier, William A., Lang, Gerald E., Parsons, David Cecil   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Guiding principles for successful mine reclamation in British Columbia

, 2020
BC’s Ministry of Energy, Mines and Petroleum Resources is developing a Reclamation Guide for Mines in British Columbia. The Guide is intended to support mine operators, regulators, Indigenous communities, and other stakeholders to improve the processes ...
Baker, T., Antill, T., Straker, J., McConnachie, J., McKenna, G.   +4 more
core   +1 more source

British Columbia mine reclamation, an overview

, 1981
The Ministry of Energy, Mines and Petroleum Resources has directed most of its activity toward enforcement of reclamation of coal mines. The many proposed coal projects have necessitated that a strong emphasis be placed on coal mine reclamation.
McDonald, J. D.
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Mine-specific B.C. reclamation funds

, 1990
Section 12 of the Mines Act (S.B.C. 1989 c.56) provides for the establishment of mine-specific reclamation funds (Funds) as security for mine reclamation obligations.
Anderson, Duane
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

History and future of mine reclamation in British Columbia

, 1992
In British Columbia, environmental protection and reclamation is a major component of all mineral exploration and mine development activity. Since 1969 mining companies have been required by law to reclaim all lands disturbed by mining. B.C.
Errington, John
core   +1 more source