Results 61 to 70 of about 2,030 (252)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Monitoring the quality of water from isolated marshes resulting from opencast and underground mining of the Sieniawa lignite deposit

E3S Web of Conferences, 2017
The „Sieniawa” lignite mine is one of the oldest Polish mines extracting lignite by means of both underground and opencast mining. The latter process is carried out until the present day.
Galiniak Grzegorz, Rόżkowski Kazimierz
doaj   +1 more source

Soil microbial legacies influence plant survival and growth in mine reclamation. [PDF]

Ecol Evol, 2022
McMahen K, Guichon SHA, Anglin CD, Lavkulich LM, Grayston SJ, Simard SW.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Resilience and synergy/trade-off relationship of soil-vegetation system in dump reclamation of surface coal mines on the Loess Plateau

Meitan xuebao
The interaction and feedback between soil and vegetation will promote the restoration of damaged mine ecosystems towards a virtuous cycle, especially in surface mine dump site reclamation areas.
Fu CHEN, Yanfeng ZHU, Zhanbin LUO, Yuanyuan CHANG, Yongjun YANG, Jing MA   +5 more
doaj   +1 more source

Laboratory simulation of the swampy forest system for the passive treatment of acid mine drainage in coal mine reclamation areas. [PDF]

Sci Rep, 2023
Noor I, Arifin YF, Priatmadi BJ, Saidy AR.   +3 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Soil and ecological assessment of the technogenically disturbed landscape in the area of a coal mine dump

Юг России: экология, развитие
Study of the soil‐ecological state of technogenic landscapes of Kuzbass through the example of coal mine dumps.Soil samples were taken in places with disturbed landscapes due to the action of the coal industry, namely the external dump on the site of the
I. V. Timoshchuk, L. K. Asyakina, A. К. Gorelkina, M. A. Osintseva, J. V. Golubtsova, I. S. Milentyeva   +5 more
doaj   +1 more source