Results 121 to 130 of about 7,040 (301)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Design of Emergency Communication Security System of Coal Mine
Gong-kuang zidonghua, 2012 The paper proposed a design scheme of emergency communication security system of coal mine. The system's core namely emergency rescue software platform integrates underground broadcast telephone, PHS, WiFi mobile phone, dispatching telephone, underground
QIAN Jian-sheng +2 more
doaj
Analysis of cycloid motor output characteristics based on fluid simulation
Alexandria Engineering JournalIn the field of drilling engineering, the rubber screw motor adopts the cycloidal principle for drilling, and the rubber bushing will carbonize and fail when the drilling at 180°C and above.
Jiaxing Lu +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Research on the advanced and applicable equipment allocation system of mine rescue teams in China
Meikuang AnquanBy systematically sorting out the classification of mining accidents in China, mining accidents are classified into two categories: underground accidents and surface accidents, and their characteristics and patterns are analyzed in depth.
Haibo DANG +7 more
doaj +1 more source
Zenith Mine, mine rescue worker
, 2022 Date scanned: 2002-5-21.USBM #59495; Operator at instrument box of mine-rescue telephone set. Zenith Mine, Pickands, Mather & Company, Ely, St. Louis County, Minnesota. (March 1945 - M. S. P).Held in the Russell L.
Petersen, Max S.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Fire and rescue service community safety initiatives: measuring impact
, 2014 Purpose - The purpose of this paper is to discuss methods of capturing the impact of fire and rescue service (FRS) community safety work which directly aims to reduce the occurrence of specific incidents.
Simpson, T +7 more
core +1 more source